Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus

Table 2 Osteopontin (OPN) and thrombin-cleaved osteopontin (N-half OPN) in relation to nephropathy and coronary artery disease

Variable	Control (n = 75)	Diabetes (n = 301)	OPN ≤ median (n = 150)	OPN >median (n = 151)	N-half OPN ≤ median (n = 150)	N-half OPN >median (n = 151)
Renal function parameters
Creatinine (μmol/L)	74.7 ± 14.6	84.8 ± 26.1^†	79.2 ± 19.5	90.3 ± 30.2*	83.9 ± 27.3	85.8 ± 24.8
eGFR (mL/min/1.73 m²)	89.6 ± 20.3	79.8 ± 20.9*	84.1 ± 19.5	75.5 ± 21.3*	80.9 ± 20.2	78.6 ± 21.5
eGFR <90 mL/min/1.73 m² (%)	45 (60)	206 (71.3)	91 (63.6)	115 (78.8)^†	106 (72.6)	100 (69.9)
eGFR <60 mL/min/1.73 m² (%)	2 (2.7)	48 (16.6)^†	16 (11.2)	32 (21.9)^‡	19 (13.0)	29 (20.3)
CAD (%)	-	226 (75.1)	104 (69.3)	122 (80.8)^‡	111 (74.0)	115 (76.2)
Inflammatory cytokines
OPN (ng/mL)	218 (190, 261)	235 (201, 284)*	201 (186, 218)	284 (258, 359)*	242 (212, 279)	226 (191, 286)
N-half OPN (pmol/L)	23.8 (18.9, 41.9)	25.3 (20.6, 34.9)	27.9 (20.8, 42.7)	23.8 (20.4, 31.4)^†	20.6 (18.7, 22.3)	34.8 (29.3, 44.3)*
HsCRP (ng/mL)	150 (102, 330)	286 (139, 675)*	206 (130, 373)	426 (173,1049)*	285 (149, 629)	288 (130, 790)

Data are given as mean ± SD or the median (interquartile ranges), as appropriate. *P < 0.001, ^†P < 0.01, ^‡P < 0.05 compared with the control group, the group with OPN values below the median value and the group with N-half OPN values below the median, respectively.
Abbreviations: eGFR, estimated glomerular filtration rate; CAD, coronary artery disease; OPN, osteopontin; N-half OPN, Thrombin-cleaved N-half osteopontin; hsCRP, high sensitive C-reactive protein.

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