Figure 1

PPARgamma activation improves systemic insulin sensitivity of HFD-fed mice. A) Glucose tolerance test (GTT) of LFD-fed, HFD-fed and vehicle-, rosiglitazone-, or telmisartan-treated mice after 10-weeks of intervention, as indicated and described in Methods, n = 10; * p < 0.05 rosiglitazone-treated mice vs. vehicle-treated animals,°p < 0.05 telmisartan-treated mice vs. vehicle-treated animals, # p < 0.05 LFD-fed vs. HFD-fed, vehicle-treated mice. B) Glucose tolerance test (GTT) of HFD-fed, vehicle-, rosiglitazone-, or telmisartan-treated mice after 5- and 10-weeks of intervention, as indicated. From each group area under the curve (AUC) was calculated, as described in Methods, n = 10;°p < 0.05 rosiglitazone-treated mice vs. vehicle-treated animals; * p < 0.05 telmisartan-treated mice vs. vehicle-treated animals.