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Table 2 Medications

From: Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study

Variable IR (+) IR(-) p-valuea NGT IGT T2DM5# p-valuea
n (%) 38 (18) 113 (54) - 64 (31) 54 (26) 90 (43) -
Glucose lowering treatment        
Metformin, n (%) 0 (0) 1 (0.9) 0.748 0 (0) 1 (2) 64 (71) <0.001*
Sulfonylurea, n (%) 0 (0) 1 (0.9) 0.748 0 (0) 0 (0) 1 (1) <0.001*
Insulin therapy, n (%) 0 (0) 0 (0) - 0 (0) 0 (0) 24 (34) <0.001*
Thiazolidinediones, n (%) 0 (0) 0 (0) - 0 (0) 0 (0) 2 (2) 0.266
Glinide, n (%) 0 (0) 0 (0) - 0 (0) 0 (0) 2 (2) 0.266
Hypertension treatment        
Beta-blocker, n (%) 23 (61) 72 (63) 0.434 33 (52) 39 (72) 62 (69) 0.033*
AT1 receptor blocker, n (%) 5 (13) 16 (14) 1.000 9 (14) 6 (11) 15 (17) 0.653
ACE-inhibitor, n (%) 24 (36) 65 (58) 0.573 31 (48) 37 (69) 55 (61) 0. 076
Calcium antagonist, n (%) 7 (18) 18 (16) 0.801 9 (14) 6 (11) 23 (26) 0.055
Diuretics, n (%) 12 (32) 31 (27) 0.679 16 (25) 16 (30) 31 (34) 0.450
Other Medications        
Nitrate, n (%) 5 (13) 7 (6) 0.181 1 (2) 7 (13) 16 (18) 0.008*
Acetyl salicylic acid, n (%) 24 (63) 76 (68) 0.691 38 (60) 40 (74) 65 (73) 0.169
Clopidrogel, n (%) 11 (29) 34 (31) 1.000 13 (21) 18 (33) 28 (32) 0.259
Allopurinol, n (%) 5 (13) 6 (5.4) 0.147 3 (5) 3 (6) 15 (17) 0.022*
Aldosterone antagonist, n (%) 1 (3) 0 (0) 0.248 0 (0) 1 (2) 0 (0) 0.245
Statin, n (%) 16 (42) 60 (53) 0.423 27 (42) 28 (52) 49 (55) 0.598
  1. Values are median (interquartile range) or n (%).a Wilcoxon-Mann-Whitney-Test, Jonckheere-Terpstra test, Fisher or χ2 Test were used as appropriate, * statistically significant (p < 0,05). #Subjects with diabetes before inclusion or new detected diabetes based on oGTT results