Distribution (n = 124) |
Quartile 1 (n = 31) |
Quartile 2 (n = 31) |
Quartile 3 (n = 31) |
Quartile 4 (n = 31) | P-value* | P-value for trend† |
---|---|---|---|---|---|---|

Cardiac troponin T (ng/L), range | ||||||

Men | 0.00 - 5.73 | 5.74 - 8.19 | 8.20 - 12.62 | 12.62 - 41.69 | ||

Women | 0.00 - 3.00 | 3.01 - 5.64 | 5.65 - 8.48 | 8.49 - 30.42 | ||

Demographic and clinical data
| ||||||

Age (years, mean, SD) | 52 (10) | 58 (8) | 62 (9) | 62 (9) | < 0.001 | < 0.001 |

BMI (kg/h2, mean, SD) | 30 (7) | 30 (4) | 31 (5) | 29 (6) | 0.586 | 0.612 |

24 h systolic BP (mm/Hg, mean, SD) | 127 (14) | 133 (10) | 136 (12) | 133 (18) | 0.079 | 0.124 |

24 h diastolic BP (mm/Hg, mean, SD) | 76 (9) | 79 (7) | 80 (7) | 76 (9) | 0.231 | 0.839 |

S-L voltage criteria (mm, mean, SD) | 21 (8) | 22 (8) | 20 (7) | 21 (9) | 0.575 | 0.908 |

Ejection fraction (%, mean, SD) | 63 (10) | 63 (8) | 63 (5) | 64 (8) | 0.907 | 0.546 |

V02 max (liters/minute, mean, SD) | 2.3 (0.6) | 2.1 (0.6) | 2.1 (0.7) | 1.9 (0.7) | 0.188 | 0.036 |

Medical history
| ||||||

Duration of diabetes (years, mean, SD) | 5 (5) | 7 (6) | 5 (6) | 10 (8) | 0.008 | 0.005 |

Coronary artery disease | 3 (10%) | 5 (16%) | 4 (13%) | 3 (10%) | 0.841 | 0.902 |

Hypertension | 18 (58%) | 21 (68%) | 21 (68%) | 24 (77%) | 0.448 | 0.124 |

Current smoker | 4 (13%) | 4 (13%) | 3 (10%) | 3 (10%) | 0.956 | 0.612 |

Laboratory determinations
| ||||||

BNP (pmol/L, geometric mean, 95^{th} percentile)
| 12 (8-18) | 8 (6-12) | 12 (8-17) | 16 (9-27) | 0.211 | 0.163 |

Cholesterol (mmol/L, mean, SD) | 4.9 (1) | 4.9 (1) | 5.2 (1) | 4.8 (1) | 0.492 | 0.740 |

CRP (g/dL, geometric mean, 95^{th} percentile)
| 3 (2-4) | 2 (2-3) | 3 (2-4) | 2 (2-3) | 0.530 | 0.554 |

Hb1Ac (%, mean, SD) | 7.4 (1) | 7.4 (2) | 7.4 (2) | 7.8 (2) | 0.641 | 0.254 |

eGFR (Cockroft-Gault) (ml/min, mean, SD) | 137 (55) | 120 (37) | 115 (37) | 102 (33) | 0.011 | 0.001 |

Microalbuminuria (ug/min, geometric mean, 95^{th} percentile)
| 15 (11-22) | 14 (11-19) | 22 (15-30) | 18 (13-25) | 0.285 | 0.306 |

Exercise ECG (n = 124)
| ||||||

Number of patients | 31 | 31 | 31 | 31 | ||

Ischemia | 9 (29%) | 8 (26 %) | 10 (32%) | 13 (42%) | 0.559 | 0.231 |

Angiography (n = 85)
| ||||||

Number of patients | 19 | 20 | 21 | 25 | ||

Coronary disease | 2 (9%) | 6 (30%) | 5 (24%) | 9 (36%) | 0.273 | 0.098 |

Stress echocardiography (n = 87)
| ||||||

Number of patients | 20 | 22 | 22 | 23 | ||

Reversible ischemia | 3 (15%) | 6 (27%) | 6 (27%) | 7 (30%) | 0.674 | 0.283 |