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Table 1 Comparison of variables between subjects stratified by cardiac troponin T levels

From: Determinants and prognostic implications of Cardiac Troponin T measured by a sensitive assay in Type 2 Diabetes Mellitus

Distribution (n = 124) Quartile 1 (n = 31) Quartile 2 (n = 31) Quartile 3 (n = 31) Quartile 4 (n = 31) P-value* P-value for trend†
Cardiac troponin T (ng/L), range
Men 0.00 - 5.73 5.74 - 8.19 8.20 - 12.62 12.62 - 41.69   
Women 0.00 - 3.00 3.01 - 5.64 5.65 - 8.48 8.49 - 30.42   
Demographic and clinical data       
Age (years, mean, SD) 52 (10) 58 (8) 62 (9) 62 (9) < 0.001 < 0.001
BMI (kg/h2, mean, SD) 30 (7) 30 (4) 31 (5) 29 (6) 0.586 0.612
24 h systolic BP (mm/Hg, mean, SD) 127 (14) 133 (10) 136 (12) 133 (18) 0.079 0.124
24 h diastolic BP (mm/Hg, mean, SD) 76 (9) 79 (7) 80 (7) 76 (9) 0.231 0.839
S-L voltage criteria (mm, mean, SD) 21 (8) 22 (8) 20 (7) 21 (9) 0.575 0.908
Ejection fraction (%, mean, SD) 63 (10) 63 (8) 63 (5) 64 (8) 0.907 0.546
V02 max (liters/minute, mean, SD) 2.3 (0.6) 2.1 (0.6) 2.1 (0.7) 1.9 (0.7) 0.188 0.036
Medical history       
Duration of diabetes (years, mean, SD) 5 (5) 7 (6) 5 (6) 10 (8) 0.008 0.005
Coronary artery disease 3 (10%) 5 (16%) 4 (13%) 3 (10%) 0.841 0.902
Hypertension 18 (58%) 21 (68%) 21 (68%) 24 (77%) 0.448 0.124
Current smoker 4 (13%) 4 (13%) 3 (10%) 3 (10%) 0.956 0.612
Laboratory determinations       
BNP (pmol/L, geometric mean, 95th percentile) 12 (8-18) 8 (6-12) 12 (8-17) 16 (9-27) 0.211 0.163
Cholesterol (mmol/L, mean, SD) 4.9 (1) 4.9 (1) 5.2 (1) 4.8 (1) 0.492 0.740
CRP (g/dL, geometric mean, 95th percentile) 3 (2-4) 2 (2-3) 3 (2-4) 2 (2-3) 0.530 0.554
Hb1Ac (%, mean, SD) 7.4 (1) 7.4 (2) 7.4 (2) 7.8 (2) 0.641 0.254
eGFR (Cockroft-Gault) (ml/min, mean, SD) 137 (55) 120 (37) 115 (37) 102 (33) 0.011 0.001
Microalbuminuria (ug/min, geometric mean, 95th percentile) 15 (11-22) 14 (11-19) 22 (15-30) 18 (13-25) 0.285 0.306
Exercise ECG (n = 124)       
Number of patients 31 31 31 31   
Ischemia 9 (29%) 8 (26 %) 10 (32%) 13 (42%) 0.559 0.231
Angiography (n = 85)       
Number of patients 19 20 21 25   
Coronary disease 2 (9%) 6 (30%) 5 (24%) 9 (36%) 0.273 0.098
Stress echocardiography (n = 87)       
Number of patients 20 22 22 23   
Reversible ischemia 3 (15%) 6 (27%) 6 (27%) 7 (30%) 0.674 0.283
  1. * P-value is for comparison between groups and derived from one-way ANOVA (contionuous variables) or Chi-Square test (categorical variables).
  2. † For continuous variables, the test for trend is based on assigning the median troponin T value for each quartile category to each person in that category and then treating these four values as a continuous, independent variable in a linear regression model. For categorical variables, the test is based on the Cochran-Armitage trend test.
  3. SD = standard deviation; BMI = body-mass index; BP = blood pressure; S-L = Sokolow-Lyon; BNP, = Brain-natriuretic peptide; CRP = C-reactive protein; eGFR = estimated glomerular filtration rate.