Figure 7

Increased p38-phosphorylation in diabetic GK rats 12 weeks after MI. Panel (A) shows an increase in total myocardial p38 protein expression in post-MI GK and Wistar rats. Panel (B) shows an increase in phosphorylated p38 in GK rats with MI. The lower panels in (A) and (B) shows representative western blots of total--p38 and phospho-p38 respectively, anti-tubulin was used as loading control. Panel (C) shows the mRNA expression of connective tissue growth factor (CTGF) in myocardial tissue and (D) shows the mRNA expression of interleukin -6 (IL-6) in myocardial tissue. Data is presented as means ± SEM; * indicates P < 0.05 vs. W (sham-operated Wistar), ^# indicates P < 0.05 vs. GK (sham-operated GK), ^† indicates P < 0.05 vs. W+MI.