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Figure 3 | Cardiovascular Diabetology

Figure 3

From: Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat

Figure 3

Sustained cardiomyocyte apoptosis in diabetic GK rats 12 weeks after MI. Results from TUNEL staining show increased cardiomyocyte apoptosis in the infarct border zone (A) and in the remote area (B) in GK rats (n = 6) 12 weeks after MI. Panel (C) shows myocardial caspase-3 protein overexpression in post--MI GK rats as assessed by western blotting. In panel (D), results from western blot shows an increase in proapoptotic Bax protein in sham- and MI operated GK rats and Wistar MI rats. The lower panels in (C) and (D) show representative western blots of myocardial tissue probed with anti-caspase-3, anti-bax and anti-tubulin. Data is presented as means ± SEM; * indicates P < 0.05 vs. W (sham-operated Wistar), # indicates P < 0.05 vs. GK (sham-operated GK), † indicates P < 0.05 vs. W+MI.

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Cardiovascular Diabetology

ISSN: 1475-2840