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Table 2 Examples of some of the genes which are statistically significant in alloxan induced diabetes in dog hearts

From: Oxidant-NO dependent gene regulation in dogs with type I diabetes: impact on cardiac function and metabolism

Affy Ids Fold-change P Values Gene Title
Metabolic genes    
Up-regulated    
1604393_at 7.31 0.01 inorganic pyrophosphatase
Down-regulated    
1582358_s_at -78.79 0.004 glyceraldehyde-3-phosphate dehydrogenase
1586136_x_at -77.17 0.006 cytochrome c oxidase, subunit VIb polypeptide 1
1604455_at -55.33 0.002 Creatine kinase M-type
1583489_s_at -54.19 0.009 NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial precursor (Complex I-23KD)
1589664_s_at -26.35 0.002 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c, isoform 1
1603350_x_at -25.11 0.003 Beta enolase (2-phospho-D-glycerate hydro-lyase)
1603755_at -24.59 0.005 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
1586831_at -24.42 0.006 Phosphoglycerate mutase 2
1583253_at -22.94 0.006 NADH-ubiquinone oxidoreductase Fe-S protein 7
1604453_at -22.63 0.003 isocitrate dehydrogenase 2 (NADP+), mitochondrial
1594799_at -22.47 0.007 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
1583615_at -20.11 0.01 inositol polyphosphate-5-phosphatase, 40kDa
1588757_at -17.75 0.003 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
1597725_s_at -17.63 0.006 3-hydroxyacyl-CoA dehydrogenase type II
1583148_at -17.39 0.008 ubiquinol-cytochrome c reductase core protein I
1583152_at -17.27 0.007 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
1583193_s_at -15.89 0.003 isocitrate dehydrogenase 3, beta subunit isoform b precursor
1592397_at -15.24 0.009 succinate-CoA ligase, GDP-forming, alpha subunit
1588432_at -14.22 0.009 cytochrome c-1
1588302_at -13.55 0.004 ubiquinol-cytochrome c reductase subunit
1583550_s_at -13.55 0.008 Vacuolar ATP synthase 16 kDa proteolipid subunit
1585498_at -12.82 0.01 Glucose-6-phosphate isomerase (GPI)
1583430_at -12.64 0.01 Triosephosphate isomerase (TIM) (Triose-phosphate isomerase)
1585763_at -12.64 0.008 Ubiquinol-cytochrome c reductase complex 11 kDa protein, mitochondrial precursor
1583348_x_at -12.55 0.006 cytochrome c oxidase, subunit VIb polypeptide 1
1604126_at -10.63 0.007 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
1584695_at -7.84 0.003 succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
1604230_at -7.73 0.006 NADH dehydrogenase 1 beta subcomplex 4
1598523_at -6.02 0.01 Glucose-6-phosphate isomerase (GPI)
1589790_s_at -6.02 0.007 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
1592755_s_at -5.24 0.008 Electron transfer flavoprotein-ubiquinone oxidoreductase
1588377_at -5.17 0.01 3-methyl-2-oxobutanoate dehydrogenase kinase
1598623_s_at -4.79 0.005 phosphofructokinase, muscle
1586218_at -4.76 0.004 Aldose reductase
1590058_s_at -4.56 0.002 creatine kinase, mitochondrial 2
1584362_at -4.44 0.01 NAD-dependent deacetylase sirtuin-3
1583716_at -4.03 0.004 aconitase 2, mitochondrial
Mitochondria proteins and transport
Down-regulated    
1583895_x_at -71.51 0.008 ribosomal protein L29
1593894_at -22.78 0.01 Mitochondrial import receptor subunit TOM22 homolog
1587993_x_at -11.47 0.008 Inner membrane protein OXA1L, mitochondrial precursor (Oxidase assembly 1-like protein)
1585706_x_at -11.39 0.008 Inner membrane protein OXA1L, mitochondrial precursor (Oxidase assembly 1-like protein)
1588228_at -9.85 0.006 Mitochondrial 39 S ribosomal protein L23 (L23mt) (MRP-L23) (L23 mitochondrial-related protein)
1592554_at -9.06 0.004 14-3-3 protein epsilon (14-3-3E) (Mitochondrial import stimulation factor L subunit) (MSF L)
1586690_at -7.89 0.01 NTF2-related export protein 1
1585137_at -7.52 0.01 Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP)
1586284_at -7.52 0.009 ATP synthase coupling factor 6, mitochondrial precursor (ATPase subunit F6)
1582738_at -7.26 0.01 FXYD domain containing ion transport regulator 1 (phospholemman)
1586934_at -7.11 0.008 Solute carrier family 2, facilitated glucose transporter, member 1 (Glucose transporter type 1)
1592219_s_at -4.44 0.01 transaldolase 1
Calcium uptake and myocardial contraction and relaxation
Up-regulated    
1606083_at 4.44 0.007 protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
Down-regulated    
1582664_s_at -48.50 0.004 troponin I type 3 (cardiac)
1582739_s_at -36.50 0.01 FXYD domain containing ion transport regulator 1 (phospholemman)
1586044_s_at -20.82 0.008 actinin, alpha 2
1585703_s_at -19.97 0.006 beta-actin///actin, gamma 1
1582670_s_at -16.56 0.006 myosin, light chain 2, regulatory, cardiac, slow
1592467_at -15.03 0.01 Tropomyosin 1 (alpha)
1605421_at -13.27 0.009 phosphodiesterase 1C, calmodulin-dependent 70kDa
1587427_at -11.24 0.008 ryanodine receptor 2 (cardiac)
1605889_at -9.85 0.004 Myosin, light polypeptide 2, regulatory, cardiac, slow
1605583_at -5.17 0.009 cardiac titin
1585044_x_at 5.13 0005 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
1589676_s_at -5.06 0.006 actin, alpha, cardiac muscle 1
1583557_at -4.86 0.008 Adenylyl cyclase-associated protein 1 (CAP 1)
1584317_at -4.86 0.005 smoothelin isoform c
1602057_s_at -4.50 0.01 calmodulin 1
1604456_at -4.44 0.004 troponin C, slow
1592238_s_at -2.40 0.01 SERCA2
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Cardiovascular Diabetology

ISSN: 1475-2840