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Table 2 Examples of some of the genes which are statistically significant in alloxan induced diabetes in dog hearts

From: Oxidant-NO dependent gene regulation in dogs with type I diabetes: impact on cardiac function and metabolism

Affy Ids

Fold-change

P Values

Gene Title

Metabolic genes

   

Up-regulated

   

1604393_at

7.31

0.01

inorganic pyrophosphatase

Down-regulated

   

1582358_s_at

-78.79

0.004

glyceraldehyde-3-phosphate dehydrogenase

1586136_x_at

-77.17

0.006

cytochrome c oxidase, subunit VIb polypeptide 1

1604455_at

-55.33

0.002

Creatine kinase M-type

1583489_s_at

-54.19

0.009

NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial precursor (Complex I-23KD)

1589664_s_at

-26.35

0.002

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c, isoform 1

1603350_x_at

-25.11

0.003

Beta enolase (2-phospho-D-glycerate hydro-lyase)

1603755_at

-24.59

0.005

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)

1586831_at

-24.42

0.006

Phosphoglycerate mutase 2

1583253_at

-22.94

0.006

NADH-ubiquinone oxidoreductase Fe-S protein 7

1604453_at

-22.63

0.003

isocitrate dehydrogenase 2 (NADP+), mitochondrial

1594799_at

-22.47

0.007

NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)

1583615_at

-20.11

0.01

inositol polyphosphate-5-phosphatase, 40kDa

1588757_at

-17.75

0.003

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7

1597725_s_at

-17.63

0.006

3-hydroxyacyl-CoA dehydrogenase type II

1583148_at

-17.39

0.008

ubiquinol-cytochrome c reductase core protein I

1583152_at

-17.27

0.007

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa

1583193_s_at

-15.89

0.003

isocitrate dehydrogenase 3, beta subunit isoform b precursor

1592397_at

-15.24

0.009

succinate-CoA ligase, GDP-forming, alpha subunit

1588432_at

-14.22

0.009

cytochrome c-1

1588302_at

-13.55

0.004

ubiquinol-cytochrome c reductase subunit

1583550_s_at

-13.55

0.008

Vacuolar ATP synthase 16 kDa proteolipid subunit

1585498_at

-12.82

0.01

Glucose-6-phosphate isomerase (GPI)

1583430_at

-12.64

0.01

Triosephosphate isomerase (TIM) (Triose-phosphate isomerase)

1585763_at

-12.64

0.008

Ubiquinol-cytochrome c reductase complex 11 kDa protein, mitochondrial precursor

1583348_x_at

-12.55

0.006

cytochrome c oxidase, subunit VIb polypeptide 1

1604126_at

-10.63

0.007

enoyl Coenzyme A hydratase, short chain, 1, mitochondrial

1584695_at

-7.84

0.003

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

1604230_at

-7.73

0.006

NADH dehydrogenase 1 beta subcomplex 4

1598523_at

-6.02

0.01

Glucose-6-phosphate isomerase (GPI)

1589790_s_at

-6.02

0.007

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa

1592755_s_at

-5.24

0.008

Electron transfer flavoprotein-ubiquinone oxidoreductase

1588377_at

-5.17

0.01

3-methyl-2-oxobutanoate dehydrogenase kinase

1598623_s_at

-4.79

0.005

phosphofructokinase, muscle

1586218_at

-4.76

0.004

Aldose reductase

1590058_s_at

-4.56

0.002

creatine kinase, mitochondrial 2

1584362_at

-4.44

0.01

NAD-dependent deacetylase sirtuin-3

1583716_at

-4.03

0.004

aconitase 2, mitochondrial

Mitochondria proteins and transport

Down-regulated

   

1583895_x_at

-71.51

0.008

ribosomal protein L29

1593894_at

-22.78

0.01

Mitochondrial import receptor subunit TOM22 homolog

1587993_x_at

-11.47

0.008

Inner membrane protein OXA1L, mitochondrial precursor (Oxidase assembly 1-like protein)

1585706_x_at

-11.39

0.008

Inner membrane protein OXA1L, mitochondrial precursor (Oxidase assembly 1-like protein)

1588228_at

-9.85

0.006

Mitochondrial 39 S ribosomal protein L23 (L23mt) (MRP-L23) (L23 mitochondrial-related protein)

1592554_at

-9.06

0.004

14-3-3 protein epsilon (14-3-3E) (Mitochondrial import stimulation factor L subunit) (MSF L)

1586690_at

-7.89

0.01

NTF2-related export protein 1

1585137_at

-7.52

0.01

Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP)

1586284_at

-7.52

0.009

ATP synthase coupling factor 6, mitochondrial precursor (ATPase subunit F6)

1582738_at

-7.26

0.01

FXYD domain containing ion transport regulator 1 (phospholemman)

1586934_at

-7.11

0.008

Solute carrier family 2, facilitated glucose transporter, member 1 (Glucose transporter type 1)

1592219_s_at

-4.44

0.01

transaldolase 1

Calcium uptake and myocardial contraction and relaxation

Up-regulated

   

1606083_at

4.44

0.007

protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)

Down-regulated

   

1582664_s_at

-48.50

0.004

troponin I type 3 (cardiac)

1582739_s_at

-36.50

0.01

FXYD domain containing ion transport regulator 1 (phospholemman)

1586044_s_at

-20.82

0.008

actinin, alpha 2

1585703_s_at

-19.97

0.006

beta-actin///actin, gamma 1

1582670_s_at

-16.56

0.006

myosin, light chain 2, regulatory, cardiac, slow

1592467_at

-15.03

0.01

Tropomyosin 1 (alpha)

1605421_at

-13.27

0.009

phosphodiesterase 1C, calmodulin-dependent 70kDa

1587427_at

-11.24

0.008

ryanodine receptor 2 (cardiac)

1605889_at

-9.85

0.004

Myosin, light polypeptide 2, regulatory, cardiac, slow

1605583_at

-5.17

0.009

cardiac titin

1585044_x_at

5.13

0005

myosin, light polypeptide 6, alkali, smooth muscle and non-muscle

1589676_s_at

-5.06

0.006

actin, alpha, cardiac muscle 1

1583557_at

-4.86

0.008

Adenylyl cyclase-associated protein 1 (CAP 1)

1584317_at

-4.86

0.005

smoothelin isoform c

1602057_s_at

-4.50

0.01

calmodulin 1

1604456_at

-4.44

0.004

troponin C, slow

1592238_s_at

-2.40

0.01

SERCA2