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Table 1 Comparisons of anthropometric and metabolic characteristics among 3 genotypes at rs2283228

From: KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population

 

Genotype

P

rs2283228

AA

AC

CC

 

Numbers

156

191

51

 

Sex, male (n/%)

77/49.3

90/47.1

27/52.9

0.746

Age, years

51.67 ± 5.50

51.28 ± 5.47

52.53 ± 5.72

0.836

Hypertension, n/%

83/53.2

121/63.3

31/60.7

0.155

Type 2 diabetes mellitus, n/%

21/13.5

29/15.2

7/13.7

0.894

Family history of CAD, n/%

64/41.0

73/38.2

17/33.3

0.609

Smokers, n/%

53/33.9

69/36.1

17/33.3

0.887

BMI, kg/m2

24.29 ± 3.46

24.93 ± 3.81

24.33 ± 3.00

0.227

FBS, mmol/L

5.73 ± 1.72

5.57 ± 0.98

5.87 ± 1.86

0.408

Insulin, mU/L

14.31 ± 11.87

13.16 ± 9.84

17.32 ± 13.08

0.351

HOMA-IR

3.64 ± 0.59

3.56 ± 0.57

4.36 ± 0.83

0.138

TC, mmol/L

4.65 ± 0.93

4.39 ± 0.86

4.63 ± 0.78

0.116

TG, mmol/L

1.53 ± 0.76

1.50 ± 0.80

2.03 ± 0.84

0.007

LDL-C, mmol/L

2.82 ± 0.80

2.71 ± 0.74

2.74 ± 0.84

0.604

HDL-C, mmol/L

1.21 ± 0.30

1.14 ± 0.25

1.07 ± 0.22

0.052

Apo A1, g/L

1.15 ± 0.18

1.11 ± 0.19

1.08 ± 0.16

0.055

Apo B, g/L

0.87 ± 0.25

0.86 ± 0.25

0.97 ± 0.23

0.115

  1. Data are mean ± SD, or number (%), as appropriate.
  2. P is the significance level of comparison of clinical and plasma parameters among 3 groups by one-way ANOVA or chi-square test.
  3. Apo A1, apolipoprotein A1; Apo B, apolipoprotein B; BMI, body mass index; CAD, coronary artery disease; FBS, fasting blood sugar; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment-insulin resistance; LDL-C, low-density lipoprotein cholesterol; SNPs, single nucleotide polymorphisms; TC, total cholesterol; TG, triglyceride.