Beneficial effects of AC3174 on renal function after 4 weeks of treatment. (A) Serum creatinine concentrations. P = 0.0003 for one-way ANOVA. (B) Glomerular filtration rate measured by creatinine clearance. P = 0.0001 for one-way ANOVA. *P ≤ 0.05 versus high salt diet. N = 3 to 14 rats per group. Mean ± SEM.