Figure 4

Beneficial effects of AC3174 on postprandial glycemic control after 4 weeks of treatment. (A) Serum glucose concentrations after an intraperitoneal bolus of glucose. No significant difference between the GLP-1 and high salt alone groups. At 30 min post-bolus, low salt, AC3174, GLP-1, and combination AC3174 plus captopril treatment significantly lowered glucose concentrations compared with high salt diet alone (P ≤ 0.05). At 60 min post-bolus, low salt, AC3174, and AC3174 plus captopril significantly lowered glucose concentrations compared with high salt diet alone (P ≤ 0.05). At 120 min post-bolus, AC3174 and AC3174 plus captopril significantly lowered glucose concentrations compared with high salt diet alone (P ≤ 0.05). No data were collected from the captopril group. (B) Serum insulin concentrations after an intraperitoneal bolus of glucose. A high salt diet lowered insulin concentrations at all post-bolus time points compared with a low salt diet (P ≤ 0.05). No significant difference between the GLP-1 and high salt groups. Captopril significantly lowered insulin concentrations at 30, 60, and 120 min post-bolus compared with a high salt diet (P ≤ 0.05). Treatment with AC3174 (alone or with captopril) significantly raised insulin concentrations at 15 and 120 min post-bolus compared with high salt diet alone (p < 0.05). *P ≤ 0.05 versus high salt diet. N = 3 to 14 rats per group. Mean ± SEM.