Development of hypertension in the DSS rat over 4 or 5 weeks of high (8% NaCl) or low (0.3% NaCl) salt diet. (A) Systolic blood pressure measured by tail cuff. No difference among groups at baseline. At week 4, systolic blood pressure was significantly lower in all groups compared with a high salt diet alone (P ≤ 0.05). The pooled-over-time mean of the low salt group was significantly different from the high salt group (p < 0.003) (B) Arterial blood pressure measured by implanted transmitter. *P ≤ 0.05 versus high salt diet alone. (C) Pulse pressure measured by implanted transmitter. *P ≤ 0.05 versus high salt diet alone. (D) Change in body weight. (E) Kaplan-Meier survival curves followed for 8 weeks. N = 7 to 10 rats per group (N = 3 to 8 for telemetry data). Mean ± SEM.