Figure 6From: Angiotensin II mediates the high-glucose-induced endothelial-to-mesenchymal transition in human aortic endothelial cellsCellular ultrastructure following HG treatment. Transmission electron microscopy depicts the change in cellular ultrastructure following HG (30 mM) exposure (magnification × 6,000). It can be seen that normal HAECs present with few microfilaments and a rough endoplasmic reticulum (A). After exposure to HG, microfilamentation and a swollen rough endoplasmic reticulum appeared in the cytoplasm (B). These changes were attenuated by treatment with irbesartan (C). 1 bar = 4 μm.Back to article page