Figure 3
From: Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
Molecular changes in right ventricular insulin signaling. Immunoblots showing Akt (A) and glycogen synthase kinase (GSK)3β (B) and glucose transporter (GLUT)4, pyruvate dehydrogenase kinase (PDK)4 and AMP activated kinase (AMPK) (E). Quantification of immunoblots showing relative phosphorylation of Akt (C) and GSK3β (D) after saline (-; open bars) or insulin (+; filled bars) injection in RV. Quantification of immunoblots showing relative protein expression of GLUT4 (F), PDK4 (G) and AMPK phosphorylation (H) in ZL rats (white bars) and ZDF rats (black bars). Data are expressed as mean ± SEM, n = 4, * p < 0.05 vs. ZL rats, $ p = 0.09 vs. ZL rats, # p < 0.05 insulin vs. saline effect.