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Table 2 Effect of Ro-31-8220 and BAY11-7082 on pulsatile frequency and cellular size of cultured cardiomyocytes

From: The signal transduction pathway of PKC/NF-κB/c-fos may be involved in the influence of high glucose on the cardiomyocytes of neonatal rats

 

diameter(μm)

pulsatile frequency(bpm/min)

Normal Glucose (5 mmol/L)

18.76 ± 0.88

57.86 ± 2.103

High Glucose (25.5 mmol/L)

25.33 ± 1.37*

70.43 ± 3.896*

High Glucose +Ro-31-8220

21.41 ± 0.80#

64.73 ± 3.336#

High Glucose + BAY11-7082

20.94 ± 0.78#

62.55 ± 2.341#

iso-osmotic mannital

19.62 ± 1.43

57.85 ± 2.572

  1. Compared with normal glucose(5 mmol/L) group, the cellular pulsatile frequency and size of cardiomyocytes cultured in high glucose(25.5 mmol/L) increased significantly, but not in iso-osmotic mannital group, after adding Ro-31-8220 and BAY11-7082, the pulsatile frequency and size of the cells all decreased significantly. The results were expressed as means ± SE (n = 100). * P < 0.05 vs control group(glucose:5 mmol/L), #P < 0.05 vs high glucose group (glucose: 25.5 mmol/L).
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Cardiovascular Diabetology

ISSN: 1475-2840