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Table 1 Effect of high glucose on pulsatile frequency and cellular size of cultured cardiomyocytes

From: The signal transduction pathway of PKC/NF-κB/c-fos may be involved in the influence of high glucose on the cardiomyocytes of neonatal rats

 

diameter(μm)

pulsatile frequency(bpm/min)

Glucose (5 mmol/L)

18.76 ± 0.88

57.86 ± 2.103

Glucose (10 mmol/L)

19.98 ± 0.81*

59.08 ± 1.947*

Glucose (15 mmol/L)

20.71 ± 0.80*#

61.16 ± 2.121*#

Glucose (20 mmol/L)

21.33 ± 0.78* Δ

63.11 ± 2.269* Δ

Glucose (25.5 mmol/L)

25.33 ± 1.37* δ

70.43 ± 3.896* δ

iso-osmotic mannital

19.62 ± 1.43

57.85 ± 2.572

  1. The pulsatile frequency and cellular size of cardiomyocytes cultured in different glucose levels increased consistent with the increased glucose levels as shown table 1. Treatment with mannital, used as an osmotic control, had no significant effect on the pulsatile frequency and cellular size of cardiomyocytes. The results were expressed as means ± SE (n = 100). * P < 0.05 vs control 5 mmol/L glucose group, #P < 0.05 vs 10 mmol/L glucose group, ΔP < 0.05 vs 15 mmol/L glucose group, δP < 0.05 vs 20 mmol/L glucose group.
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Cardiovascular Diabetology

ISSN: 1475-2840