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Table 1 Baseline clinical and biochemical characteristics between aspirin users and non-users in the complete cohort (n = 6,454)

From: Lack of benefits for prevention of cardiovascular disease with aspirin therapy in type 2 diabetic patients - a longitudinal observational study

 

Overall

(n = 6,454)

Aspirin users

(n = 1,619)

Non-aspirin users

(n = 4,835)

p-value‡

Age, years

58.0 ± 12.8

65.7 ± 10.2

55.4 ± 12.6

< 0.001

Male, n (%)

2,928 (45.4)

819 (50.6)

2,109 (43.6)

< 0.001

Duration of diabetes, years

8.1 ± 6.9

11.4 ± 7.5

7.0 ± 6.3

< 0.001

Smoking (current), n (%)

1,033 (16.1)

253 (15.7)

780 (16.2)

< 0.001

Alcohol (current), n (%)

517 (8.1)

100 (6.2)

417 (8.7)

< 0.001

Systolic blood pressure, mmHg

136.2 ± 20.3

142.6 ± 21.7

134.1 ± 19.4

< 0.001

Diastolic blood pressure, mmHg

75.1 ± 10.6

75.1 ± 11.2

75.1 ± 10.3

0.848

Body weight, kg

63.4 ± 12.3

63.3 ± 11.8

63.5 ± 12.5

0.583

Body mass index, kg/m2

25.2 ± 3.9

25.3 ± 3.7

25.2 ± 4.0

0.135

Waist circumference (cm): Males

88.7 ± 9.6

90.1 ± 8.7

88.4 ± 9.8

< 0.001

Females

83.8 ± 10.0

85.5 ± 9.9

83.6 ± 9.9

< 0.001

Glycosylated haemoglobin, %

7.59 ± 1.69

7.72 ± 1.68

7.57 ± 1.69

< 0.001

Fasting plasma glucose, mmol/L

8.59 ± 3.10

8.57 ± 3.18

8.59 ± 3.09

0.046

Total cholesterol, mmol/L

5.21 ± 1.05

5.09 ± 1.06

5.23 ± 1.05

0.167

LDL cholesterol, mmol/L

3.19 ± 0.95

3.06 ± 0.97

3.21 ± 0.94

0.286

HDL cholesterol, mmol/L

1.30 ± 0.38

1.26 ± 0.33

1.31 ± 0.39

< 0.001

Serum triglycerides, mmol/L †

1.45 (1.43, 1.47)

1.58 (1.53, 1.64)

1.43 (1.41, 1.45)

< 0.001

Serum creatinine, μmol/L †

83.2 (82.4, 83.9)

97.1 (95.0, 99.2)

79.1 (78.3, 79.8)

< 0.001

Estimated GFR#

74.6 (73.8, 75.3)

58.6 (56.8, 60.5)

77.6 (76.8, 78.5)

< 0.001

Spot urine ACR, mg/mmol †

3.7 (3.6, 3.9)

8.3 (7.4, 9.2)

2.9 (2.7, 3.0)

< 0.001

Blood haemoglobin, g/dL

13.7 ± 1.6

13.4 ± 1.7

13.8 ± 1.6

< 0.001

Peripheral vascular disease, n (%)

400 (6.2)

223 (13.8)

177 (3.7)

< 0.001

Lower extremity amputation, n (%)

26 (0.4)

13 (0.8)

13 (0.3)

0.003

Ischaemic heart disease, n (%)

281 (4.4)

240 (14.8)

41 (0.8)

< 0.001

Myocardial infarction, n (%)

67 (1)

65 (4)

2 (0)

< 0.001

Coronary revascularisation, n (%)

77 (1.2)

75 (4.6)

2 (0)

< 0.001

Congestive heart failure, n (%)

119 (1.8)

85 (5.3)

34 (0.7)

< 0.001

Stroke, n (%)

256 (4)

221 (13.7)

35 (0.7)

< 0.001

Atrial fibrillation, n (%)

70 (1.1)

35 (2.2)

35 (0.7)

< 0.001

  1. Mean ± SD or number of patients (%) or † geometric mean (95% confidence interval).
  2. ‡ By Chi-square test for categorical variables and t-test for continuous variables
  3. #Based on the abbreviated MDRD (Modification of Diet in Renal Disease) equation for Chinese (ref. 42)
  4. LDL and HDL = low- and high-density lipoprotein, ACR = albumin-to-creatinine ratio, GFR = glomerular filtration rate.
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Cardiovascular Diabetology

ISSN: 1475-2840