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Table 4 Multivariate Association of MMP-1 and MMP-9 serum levels and quantity of non-calcified, mixed and calcified plaques as assessed by CT-angiography

From: MMP-1 serum levels predict coronary atherosclerosis in humans

Non-calcified Plaque

MMP-1

MMP-9

Adjusted for

OR (CI)

P value

OR (CI)

P value

Age, Gender, BMI

1.19 (1.04 to 1.37)

0.012

0.99 (0.95 to 1.04)

0.74

Age, Gender, BMI, RF*

1.19 (1.03 to 1.37)

0.017

0.99 (0.95 to 1.04)

0.76

Age, Gender, BMI, RF*, CRP

1.20 (1.04 to 1.38)

0.014

1 (0.95 to 1.05)

0.90

Age, Gender, BMI, RF*, CRP, AD, PCF

1.18 (1.03 to 1.37)

0.021

0.99 (0.94 to 1.04)

0.80

Age, Gender, BMI, RF*, CRP, AD, PCF, Med

1.16 (1.00 to 1.34)

0.050

1 (0.95 to 1.05)

0.90

Mixed Plaque

MMP-1

MMP-9

Adjusted for

OR (CI)

P value

OR (CI)

P value

Age, Gender, BMI

1.19 (1.03 to 1.38)

0.019

0.99 (0.94 to 1.04)

0.71

Age, Gender, BMI, RF*

1.19 (1.02 to 1.39)

0.014

0.99 (0.94 to 1.04)

0.77

Age, Gender, BMI, RF*, CRP

1.19 (1.02 to 1.39)

0.024

0.99 (0.94 to 1.05)

0.79

Age, Gender, BMI, RF*, CRP, AD, PCF

1.17 (1.00 to 1.37)

0.047

0.99 (0.94 to 1.04)

0.67

Age, Gender, BMI, RF*, CRP, AD, PCF, Med

1.14 (0.96 to 1.35)

0.12

0.99 (0.94 to 1.05)

0.83

Calcified Plaque

MMP-1

MMP-9

Adjusted for

OR (CI)

P value

OR (CI)

P value

Age, Gender, BMI

1.22 (1.04 to 1.43)

0.013

0.99 (0.94 to 1.05)

0.78

Age, Gender, BMI, RF*

1.22 (1.04 to 1.43)

0.016

0.98 (0.93 to 1.04)

0.69

Age, Gender, BMI, RF*, CRP

1.21 (1.03 to 1.42)

0.020

0.98 (0.93 to 1.04)

0.49

Age, Gender, BMI, RF*, CRP, AD, PCF

1.21 (1.03 to 1.43)

0.019

0.98 (0.94 to 1.05)

0.57

Age, Gender, BMI, RF*, CRP, AD, PCF, Med

1.22 (1.03 to 1.45)

0.023

0.98 (0.9 w to 1.05)

0.64

  1. Odds ratio and 95% CI increase in plaque quantity for 1 ng/ml (MMP-1) and 20 ng/ml (MMP-9) raise in serum levels are presented.
  2. *Risk factors (RF*) included LDL-cholesterol, HDL-cholesterol, triglycerides, cigarette smoking, hypertension, diabetes, family history for CVD.
  3. Abbreviations: CRP (hsCRP), AD (adiponectin), PCF (pericardial fat volume), Med (medication)