Table 2 Classification of differentially expressed genes between healthy controls and DM1 patients according to gene ontology (GO) terms with a p value < 0.01.
Term | Category | % of genes in category | p value |
|---|---|---|---|
GO:0032501 | multicellular organismal process | 32,02 | 9,28E-09 |
GO:0007275 | multicellular organismal development | 21,45 | 1,93E-07 |
GO:0048856 | anatomical structure development | 19,24 | 3,11E-06 |
GO:0007267 | cell-cell signaling | 7,89 | 5,22E-06 |
GO:0006812 | cation transport | 6,94 | 5,94E-06 |
GO:0048731 | system development | 16,25 | 6,22E-06 |
GO:0032502 | developmental process | 26,18 | 1,94E-05 |
GO:0006811 | ion transport | 8,99 | 2,27E-05 |
GO:0030001 | metal ion transport | 5,52 | 7,57E-05 |
GO:0009605 | response to external stimulus | 7,10 | 1,11E-04 |
GO:0015672 | monovalent inorganic cation transport | 4,57 | 1,19E-04 |
GO:0048513 | organ development | 11,83 | 1,56E-04 |
GO:0006813 | potassium ion transport | 2,84 | 2,01E-04 |
GO:0051179 | localization | 24,29 | 4,04E-04 |
GO:0006091 | generation of precursor metabolites and energy | 6,78 | 4,90E-04 |
GO:0007167 | enzyme linked receptor protein signaling pathway | 3,79 | 5,36E-04 |
GO:0003012 | muscle system process | 2,68 | 6,04E-04 |
GO:0006936 | muscle contraction | 2,68 | 6,04E-04 |
GO:0019226 | transmission of nerve impulse | 4,26 | 7,76E-04 |
GO:0007188 | G-protein signaling, coupled to cAMP nucleotide second messenger | 1,74 | 1,35E-03 |
GO:0008283 | cell proliferation | 7,57 | 1,65E-03 |
GO:0006950 | response to stress | 9,62 | 1,76E-03 |
GO:0008284 | positive regulation of cell proliferation | 3,15 | 1,97E-03 |
GO:0009611 | response to wounding | 4,73 | 1,99E-03 |
GO:0007189 | G-protein signaling, adenylate cyclase activating pathway | 1,10 | 2,11E-03 |
GO:0019933 | cAMP-mediated signaling | 1,74 | 2,27E-03 |
GO:0006954 | inflammatory response | 3,63 | 2,53E-03 |
GO:0007154 | cell communication | 29,50 | 2,75E-03 |
GO:0007155 | cell adhesion | 7,26 | 2,76E-03 |
GO:0022610 | biological adhesion | 7,26 | 2,76E-03 |
GO:0006928 | cell motility | 4,57 | 2,81E-03 |
GO:0051674 | localization of cell | 4,57 | 2,81E-03 |
GO:0030041 | actin filament polymerization | 0,95 | 3,08E-03 |
GO:0044262 | cellular carbohydrate metabolic process | 3,94 | 3,72E-03 |
GO:0007156 | homophilic cell adhesion | 2,21 | 3,85E-03 |
GO:0006952 | defense response | 5,68 | 4,07E-03 |
GO:0031279 | regulation of cyclase activity | 1,10 | 4,16E-03 |
GO:0051339 | regulation of lyase activity | 1,10 | 4,16E-03 |
GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger | 1,89 | 4,78E-03 |
GO:0016051 | carbohydrate biosynthetic process | 1,89 | 4,78E-03 |
GO:0019317 | fucose catabolic process | 0,63 | 5,29E-03 |
GO:0042355 | L-fucose catabolic process | 0,63 | 5,29E-03 |
GO:0007173 | epidermal growth factor receptor signaling pathway | 0,95 | 5,72E-03 |
GO:0007268 | synaptic transmission | 3,47 | 5,92E-03 |
GO:0001501 | skeletal development | 2,84 | 6,00E-03 |
GO:0008154 | actin polymerization and/or depolymerization | 1,26 | 6,04E-03 |
GO:0007610 | behavior | 3,63 | 6,90E-03 |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 2,52 | 6,99E-03 |
GO:0019935 | cyclic-nucleotide-mediated signaling | 1,89 | 7,81E-03 |
GO:0003008 | system process | 11,67 | 8,19E-03 |
GO:0007626 | locomotory behavior | 2,52 | 8,37E-03 |
GO:0042127 | regulation of cell proliferation | 4,89 | 8,47E-03 |
GO:0001666 | response to hypoxia | 1,10 | 9,08E-03 |
GO:0042354 | L-fucose metabolic process | 0,63 | 9,17E-03 |
GO:0043085 | positive regulation of catalytic activity | 2,84 | 9,54E-03 |