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Table 2 Classification of differentially expressed genes between healthy controls and DM1 patients according to gene ontology (GO) terms with a p value < 0.01.

From: Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes: a case-control pilot study

Term Category % of genes in category p value
GO:0032501 multicellular organismal process 32,02 9,28E-09
GO:0007275 multicellular organismal development 21,45 1,93E-07
GO:0048856 anatomical structure development 19,24 3,11E-06
GO:0007267 cell-cell signaling 7,89 5,22E-06
GO:0006812 cation transport 6,94 5,94E-06
GO:0048731 system development 16,25 6,22E-06
GO:0032502 developmental process 26,18 1,94E-05
GO:0006811 ion transport 8,99 2,27E-05
GO:0030001 metal ion transport 5,52 7,57E-05
GO:0009605 response to external stimulus 7,10 1,11E-04
GO:0015672 monovalent inorganic cation transport 4,57 1,19E-04
GO:0048513 organ development 11,83 1,56E-04
GO:0006813 potassium ion transport 2,84 2,01E-04
GO:0051179 localization 24,29 4,04E-04
GO:0006091 generation of precursor metabolites and energy 6,78 4,90E-04
GO:0007167 enzyme linked receptor protein signaling pathway 3,79 5,36E-04
GO:0003012 muscle system process 2,68 6,04E-04
GO:0006936 muscle contraction 2,68 6,04E-04
GO:0019226 transmission of nerve impulse 4,26 7,76E-04
GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger 1,74 1,35E-03
GO:0008283 cell proliferation 7,57 1,65E-03
GO:0006950 response to stress 9,62 1,76E-03
GO:0008284 positive regulation of cell proliferation 3,15 1,97E-03
GO:0009611 response to wounding 4,73 1,99E-03
GO:0007189 G-protein signaling, adenylate cyclase activating pathway 1,10 2,11E-03
GO:0019933 cAMP-mediated signaling 1,74 2,27E-03
GO:0006954 inflammatory response 3,63 2,53E-03
GO:0007154 cell communication 29,50 2,75E-03
GO:0007155 cell adhesion 7,26 2,76E-03
GO:0022610 biological adhesion 7,26 2,76E-03
GO:0006928 cell motility 4,57 2,81E-03
GO:0051674 localization of cell 4,57 2,81E-03
GO:0030041 actin filament polymerization 0,95 3,08E-03
GO:0044262 cellular carbohydrate metabolic process 3,94 3,72E-03
GO:0007156 homophilic cell adhesion 2,21 3,85E-03
GO:0006952 defense response 5,68 4,07E-03
GO:0031279 regulation of cyclase activity 1,10 4,16E-03
GO:0051339 regulation of lyase activity 1,10 4,16E-03
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 1,89 4,78E-03
GO:0016051 carbohydrate biosynthetic process 1,89 4,78E-03
GO:0019317 fucose catabolic process 0,63 5,29E-03
GO:0042355 L-fucose catabolic process 0,63 5,29E-03
GO:0007173 epidermal growth factor receptor signaling pathway 0,95 5,72E-03
GO:0007268 synaptic transmission 3,47 5,92E-03
GO:0001501 skeletal development 2,84 6,00E-03
GO:0008154 actin polymerization and/or depolymerization 1,26 6,04E-03
GO:0007610 behavior 3,63 6,90E-03
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 2,52 6,99E-03
GO:0019935 cyclic-nucleotide-mediated signaling 1,89 7,81E-03
GO:0003008 system process 11,67 8,19E-03
GO:0007626 locomotory behavior 2,52 8,37E-03
GO:0042127 regulation of cell proliferation 4,89 8,47E-03
GO:0001666 response to hypoxia 1,10 9,08E-03
GO:0042354 L-fucose metabolic process 0,63 9,17E-03
GO:0043085 positive regulation of catalytic activity 2,84 9,54E-03