Table 1 Key processes in restenosis in diabetics; the processes are specified to the elevated (↑) or decreased (↓) factors contributing to the elevated risk of restenosis in diabeticscompared to non-diabetics.
Influence of 4 Key Factors on Restenosis in Diabetics | |
|---|---|
Process | Factor |
Proinflammatory state | ↑ C-peptide |
|  | ↑ Resistin |
|  | ↑ CRP |
|  | ↑ Il-12 |
Prothrombotic state | ↑ P2Y-receptor |
|  | ↑ Endothelial damage by O2-radicals |
Accelerated and unstable plaque formation | ↑ Vascular smooth muscle cell proliferation |
|  | ↑ Macrophage infiltration |
|  | ↑ Lipid-rich |
|  | ↑ Collagen-rich |
|  | ↑ Vaso vasorum neovascularization |
Haemodynamics | ↓ Vessel lumen diameter |
|  | ↑ Multivessel disease |
|  | ↑ Viscosity |