Figure 2

Actuarial survival curves of all-cause mortality after multivariate analysis in the same population as in Figure 1. Multivariate analysis included age, gender, glucose, cholesterol, triglycerides, previous myocardial infarction, anginal syndrome, hypertension, functional class, previous cerebrovascular accident, peripheral vascular disease, smoking, body mass index and use of beta blockers and antiplatelet drugs. With patients on diet as reference group, the combined treatment with metformin and glibenclamide was associated with a significantly higher hazard ratio of all cause mortality: 1.53 (95% CI 120–1.96. (Modified from Ref. [45]).