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Figure 1 | Cardiovascular Diabetology

Figure 1

From: Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats

Figure 1

Effect of phenylephrine (panel A) and acetylcholine (panel B) on aortic strips isolated from normoglycemic (group N), normoglycemic in vivo losartan treated (group NL), diabetic (group D) and diabetic in vivo losartan treated (group DL) rats. Cumulative concentration-response curves of agonists were performed on thoracic aortic strips stretched to 0.7 g resting tension with an endothelial-intact layer. Values are the mean ± SEM of at least 4 experiments. Panel A) phenylephrine contraction. Panel B) acethylcholine effect was evaluated on 100 nM phenylephryne (Phe) pre-contracted thoracic aortic strips (100% of contraction).

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Cardiovascular Diabetology

ISSN: 1475-2840