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Table 2 Characteristics of studied groups

From: HNF1A gene polymorphisms and cardiovascular risk factors in individuals with late-onset autosomal dominant diabetes: a cross-sectional study

 

CT2DM

LOADDM

N

p

N vs CT2DM

N vs LOADDM

n

48

18

42

NS

NS

age (years)

65.6 ± 7.1

67.4 ± 10.8

63.0 ± 11.2

NS

NS

age at diagnosis (years)

54.9 ± 8.4

54.7 ± 10.0

-

-

-

weight (kg)

73.2 ± 13.7

73.4 ± 15.3

61.4 ± 13.4

<0.01

<0.05

BMI (kg/m2)

28.7 ± 4.2

28.5 ± 4.3

25.3 ± 3.7

<0.01

<0.05

waist (cm)

98.7 ± 10.7

99.4 ± 13.0

86.3 ± 9.9

<0.01

<0.01

Systolic BP (mmHg)

125.3 ± 16.0

118.0 ± 13.6

130.1 ± 17.3

NS

<0.05

Diastolic BP (mmHg)

75.2 ± 7.6

72.6 ± 8.7

81.8 ± 9.0

<0.01

<0.01

FBG (mmol/l)

7.18 ± 1.69

6.41 ± 1.91

4.98 ± 0.33

<0.01

<0.01

A1c (%)

6.4 ± 2.4

7.4 ± 1.2

5.5 ± 0.6

0.07

<0.01

total cholesterol (mmol/l)

4.44 ± 0.87

4.56 ± 0.97

4.94 ± 1.04

<0.05

NS

HDL-cholesterol (mmol/l)

1.23 ± 0.35

1.18 ± 0.28

1.43 ± 0.43

<0.05

0.07

LDL-cholesterol (mmol/l)

2.35 ± 0.64

2.64 ± 0.86

2.96 ± 0.84

<0.01

NS

triglycerides (mmol/l)

1.45 (1.07–2.07)

1.36 (1.05–1.84)

1.14 (0.78–1.48)

<0.05

NS

HOMA-%B1

77.1 ± 42.7

80.5 ± 46.1

107.8 ± 40.0

<0.01

NS

HOMA-IR1

2.12 ± 1.28

2.43 ± 1.39

1.27 ± 0.64

<0.05

NS

fasting C-peptide (nmol/l)

0.78 ± 0.50

0.77 ± 0.56

0.57 ± 0.29

NS

NS

    

p 2

females (%)

68.8

72.2

83.3

NS

hypertension (%)

85.4

72.2

50

<0.01

obesity (%)

31.3

22.2

11.9

NS

overweight (%)

83.3

66.7

52.4

<0.01

central obesity (%)

62.5

61.1

38.1

0.051

low HDL (%)

63.8

50

34.1

<0.05

hypertriglyceridemia (%)

38.8

33.3

17.7

NS

dyslipidemia treatment (%)3

8.3

0

7.1

NS

metabolic syndrome (%)

87.5

77.8

11.9

<0.01

insulin treatment (%)4

14.9

37.5

-

0.054

positive GADA (%)

4.9

0

2.6

NS

  1. 1calculated in 39 individuals from group CT2DM, 14 from LOADDM, and 39 from N; 2Two df significance, except 4(one df); 3current or previous use of fibrates/statins; NS denotes p< 0.10