|
Drugs
|
Systolic/Diastolic
|
Fall in blood pressure (mmHg (95%CI))
|
|---|
|
Thiazides
|
Systolic
|
8.8 (8.3 to 9.4)
|
| |
Diastolic
|
4.4 (4.0 to 4.8)
|
|
Beta-blockers
|
Systolic
|
9.2 (8.6 to 9.9)
|
| |
Diastolic
|
6.7 (6.2 to 7.1)
|
|
ACE inhibitors
|
Systolic
|
8.5 (7.9 to 9.0)
|
| |
Diastolic
|
4.7 (4.4 to 5.0)
|
|
Angiotensin II receptor antagonists
|
Systolic
|
10.3 (9.9 to 10.8)
|
| |
Diastolic
|
5.7 (5.4 to 9.0)
|
|
Calcium channel blockers
|
Systolic
|
8.8 (8.3 to 9.2)
|
| |
Diastolic
|
5.9 (5.6 to 6.2)
|
- In each category, the fall in blood pressure was standardised to the average starting blood pressure across all trials of 154 mmHg systolic and 97 mmHg diastolic; the estimates are the average over 24 hours from combining separate peak and trough estimates.
