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Table 4 Evolution of plasma TAG and NEFA (measured in the fed state) in control rats and in ZDF rats receiving or not fenofibrate (F) or metformin (M).

From: Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model – the Zucker diabetic rat

TAG mM

Control

ZDF

ZDF + F

ZDF + M

7 weeks

0.89 ± 0.06

2.85 ± 0.39 ***

4.09 ± 0.44 ***

3.32 ± 0.29 ***

14 weeks

1.34 ± 0.08

10.40 ± 1.10 ***

6.50 ± 1.19 ***$

8.60 ± 1.07 ***

21 weeks

1.50 ± 0.12

9.86 ± 0.63 ***

12.10 ± 1.42 ***

13.20 ± 0.57 ***

NEFA μM

    

7 weeks

550 ± 62

435 ± 43

541 ± 64

523 ± 89

14 weeks

541 ± 64

1062 ± 103 ***

869 ± 107 ***

1098 ± 123 **

21 weeks

416 ± 27

824 ± 115 **

1121 ± 145 ***

1211 ± 104 ***

  1. Results are shown are mean and sem** p < 0.01, *** p < 0.001 vs the corresponding control group; $ p < 0.05 vs the corresponding ZDF group.