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Table 2 Evolution of plasma glucose and insulin (fed state) in control rats and in ZDF rats receiving or not fenofibrate (F) or metformin (M).

From: Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model – the Zucker diabetic rat

Glucose mM Control ZDF ZDF + F ZDF + M
7 weeks 7.4 ± 0.3 7.3 ± 0.3 7.6 ± 0.2 7.4 ± 0.3
14 weeks 7.0 ± 0.4 30.1 ± 0.9*** 31.5 ± 0.5*** 31.6 ± 0.6***
21 weeks 7.6 ± 0.3 30.2 ± 0.2 *** 33.2 ± 0.2*** 34.2 ± 0.4***
Insulin ng/l     
7 weeks 4.7 ± 0.7 16.0 ± 3.0** 12.7 ± 0.8** 12.4 ± 1.1**
14 weeks 6.8 ± 1.1 4.3 ± 1.0 5.1 ± 0.7 6.3 ± 0.7
21 weeks 8.5 ± 0.5 <0.5 ** <0.5 ** <0.5 **
  1. Results are shown are mean and sem. ** p < 0.01, *** p < 0.001 vs the corresponding control