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Table 2 Evolution of plasma glucose and insulin (fed state) in control rats and in ZDF rats receiving or not fenofibrate (F) or metformin (M).

From: Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model – the Zucker diabetic rat

Glucose mM

Control

ZDF

ZDF + F

ZDF + M

7 weeks

7.4 ± 0.3

7.3 ± 0.3

7.6 ± 0.2

7.4 ± 0.3

14 weeks

7.0 ± 0.4

30.1 ± 0.9***

31.5 ± 0.5***

31.6 ± 0.6***

21 weeks

7.6 ± 0.3

30.2 ± 0.2 ***

33.2 ± 0.2***

34.2 ± 0.4***

Insulin ng/l

    

7 weeks

4.7 ± 0.7

16.0 ± 3.0**

12.7 ± 0.8**

12.4 ± 1.1**

14 weeks

6.8 ± 1.1

4.3 ± 1.0

5.1 ± 0.7

6.3 ± 0.7

21 weeks

8.5 ± 0.5

<0.5 **

<0.5 **

<0.5 **

  1. Results are shown are mean and sem. ** p < 0.01, *** p < 0.001 vs the corresponding control
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Cardiovascular Diabetology

ISSN: 1475-2840