Table 3 Genotypic and allelic distributions of RAAS gene polymorphisms
Genotypes and Alleles | Group 1 n (%) | Group 2 n (%) | Group 3 n (%) | Group 4 n (%) |
|---|---|---|---|---|
A6G Genotypes AA | 43 (61.43) | 50 (83.30) | 40 (61.54) | 68 (90.67) |
AG | 20 (28.57) | 7 (11.70) | 17 (26.15) | 6 (8.00) |
GG | 7 (10.00) | 3 (5.00) | 8 (12.31) | 1 (1.33) |
A6G Alleles C | 106 (75.71) | 107 (89.17) | 97 (74.62) | 142 (94.67) |
T | 34 (24.29) | 13 (10.83) | 33 (25.38) | 8 (5.33) |
p value Odds ratio (95% CI) | < 0.001* 1.76 (0.08–0.39) | 0.112 0.46 (0.19–1.16) | < 0.001* 1.66 (0.07–0.37) | - |
A20C Genotypes AA | 46 (65.70) | 37 (61.7) | 45 (69.23) | 53 (70.67) |
AC | 21 (30.00) | 22 (36.7) | 19 (29.23) | 21 (28.00) |
CC | 3 (4.30) | 1 (1.6) | 1 (1.54) | 1 (1.33) |
A20C Alleles A | 113 (80.70) | 96 (80.00) | 109 (83.80) | 127 (84.67) |
C | 27 (19.30) | 24 (20.00) | 21 (16.20) | 23 (15.33) |
p value Odds ratio (95% CI) | 0.437 0.76 (0.41–1.40) | 0.336 0.72 (0.39–1.36) | 0.871 0.94 (0.49–1.71) | - |
MboI Genotypes (-/-) | 46 (65.71) | 43 (71.67) | 47 (72.31) | 56 (74.67) |
(-/+) | 22 (31.43) | 16 (26.67) | 15 (23.08) | 18 (24.00) |
(+/+) | 2 (2.86) | 1 (1.67) | 3 (4.62) | 1 (1.33) |
MboI Alleles (-) | 114 (81.43) | 102 (85.00) | 109 (83.85) | 130 (86.67) |
(+) | 26 (18.57) | 18 (15.00) | 21 (16.15) | 20 (13.33) |
p value Odds ratio (95% CI) | 0.261 0.67 (0.36–1.27) | 0.727 0.87 (0.44–1.73) | 0.612 0.80 (0.41–1.55) | |
Lys173Arg Genotypes Lys173/Lys | 37 (52.86) | 22 (36.66) | 34 (52.31) | 37 (49.33) |
Lys173/Arg | 31 (44.28) | 37 (61.67) | 30 (46.15) | 37 (49.33) |
Arg173/Arg | 2 (2.86) | 1 (1.67) | 1 (1.54) | 1 (1.34) |
Lys173Arg Alleles Lys173 | 105 (75.00) | 81 (67.50) | 98 (75.38) | 111 (74.00) |
Arg173 | 35 (25.00) | 39 (32.50) | 32 (24.62) | 39 (26.00) |
p value Odds ratio (95% CI) | 0.893 1.05 (0.62–1.79) | 0.280 0.73 (0.43–1.24) | 0.891 1.08 (0.63–1.85) | - |
Gly460Trp Genotypes Gly460/Gly | 36 (51.43) | 28 (46.67) | 26 (40.00) | 40 (53.33) |
Gly460/Trp | 13 (18.57) | 21 (35.00) | 17 (26.15) | 21 (28.00) |
Trp460/Trp | 21 (30.00) | 11 (18.33) | 22 (33.85) | 14 (18.67) |
Gly460Trp Alleles Gly460 | 85 (60.71) | 77 (64.17) | 69 (53.08) | 96 (64.00) |
Trp460 | 55 (39.29) | 43 (35.83) | 61 (46.92) | 54 (36.00) |
p value Odds ratio (95% CI) | 0.564 0.87 (0.54–1.40) | 1.000 1.01 (0.61–1.66) | 0.064 0.63 (0.39–1.03) | - |