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Table 3 Genotypic and allelic distributions of RAAS gene polymorphisms

From: Analysis of renin-angiotensin aldosterone system gene polymorphisms in malaysian essential hypertensive and type 2 diabetic subjects

Genotypes and Alleles

Group 1

n (%)

Group 2

n (%)

Group 3

n (%)

Group 4

n (%)

A6G Genotypes

AA

43 (61.43)

50 (83.30)

40 (61.54)

68 (90.67)

AG

20 (28.57)

7 (11.70)

17 (26.15)

6 (8.00)

GG

7 (10.00)

3 (5.00)

8 (12.31)

1 (1.33)

A6G Alleles

C

106 (75.71)

107 (89.17)

97 (74.62)

142 (94.67)

T

34 (24.29)

13 (10.83)

33 (25.38)

8 (5.33)

p value

Odds ratio (95% CI)

< 0.001*

1.76 (0.08–0.39)

0.112

0.46 (0.19–1.16)

< 0.001*

1.66 (0.07–0.37)

-

A20C Genotypes

AA

46 (65.70)

37 (61.7)

45 (69.23)

53 (70.67)

AC

21 (30.00)

22 (36.7)

19 (29.23)

21 (28.00)

CC

3 (4.30)

1 (1.6)

1 (1.54)

1 (1.33)

A20C Alleles

A

113 (80.70)

96 (80.00)

109 (83.80)

127 (84.67)

C

27 (19.30)

24 (20.00)

21 (16.20)

23 (15.33)

p value

Odds ratio (95% CI)

0.437

0.76 (0.41–1.40)

0.336

0.72 (0.39–1.36)

0.871

0.94 (0.49–1.71)

-

MboI Genotypes

(-/-)

46 (65.71)

43 (71.67)

47 (72.31)

56 (74.67)

(-/+)

22 (31.43)

16 (26.67)

15 (23.08)

18 (24.00)

(+/+)

2 (2.86)

1 (1.67)

3 (4.62)

1 (1.33)

MboI Alleles

(-)

114 (81.43)

102 (85.00)

109 (83.85)

130 (86.67)

(+)

26 (18.57)

18 (15.00)

21 (16.15)

20 (13.33)

p value

Odds ratio (95% CI)

0.261

0.67 (0.36–1.27)

0.727

0.87 (0.44–1.73)

0.612

0.80 (0.41–1.55)

 

Lys173Arg Genotypes

Lys173/Lys

37 (52.86)

22 (36.66)

34 (52.31)

37 (49.33)

Lys173/Arg

31 (44.28)

37 (61.67)

30 (46.15)

37 (49.33)

Arg173/Arg

2 (2.86)

1 (1.67)

1 (1.54)

1 (1.34)

Lys173Arg Alleles

Lys173

105 (75.00)

81 (67.50)

98 (75.38)

111 (74.00)

Arg173

35 (25.00)

39 (32.50)

32 (24.62)

39 (26.00)

p value

Odds ratio (95% CI)

0.893

1.05 (0.62–1.79)

0.280

0.73 (0.43–1.24)

0.891

1.08 (0.63–1.85)

-

Gly460Trp Genotypes

Gly460/Gly

36 (51.43)

28 (46.67)

26 (40.00)

40 (53.33)

Gly460/Trp

13 (18.57)

21 (35.00)

17 (26.15)

21 (28.00)

Trp460/Trp

21 (30.00)

11 (18.33)

22 (33.85)

14 (18.67)

Gly460Trp Alleles

Gly460

85 (60.71)

77 (64.17)

69 (53.08)

96 (64.00)

Trp460

55 (39.29)

43 (35.83)

61 (46.92)

54 (36.00)

p value

Odds ratio (95% CI)

0.564

0.87 (0.54–1.40)

1.000

1.01 (0.61–1.66)

0.064

0.63 (0.39–1.03)

-

  1. Data are reported as number of subjects with percent in parentheses, Group 1- EHT, Group 2 -T2DM, Group 3- EHT+T2DM and Group 4-Control subjects,*P value < 0.001 vs. Group 4.