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Table 3 Genotypic and allelic distributions of RAAS gene polymorphisms

From: Analysis of renin-angiotensin aldosterone system gene polymorphisms in malaysian essential hypertensive and type 2 diabetic subjects

Genotypes and Alleles Group 1
n (%)
Group 2
n (%)
Group 3
n (%)
Group 4
n (%)
A6G Genotypes
AA
43 (61.43) 50 (83.30) 40 (61.54) 68 (90.67)
AG 20 (28.57) 7 (11.70) 17 (26.15) 6 (8.00)
GG 7 (10.00) 3 (5.00) 8 (12.31) 1 (1.33)
A6G Alleles
C
106 (75.71) 107 (89.17) 97 (74.62) 142 (94.67)
T 34 (24.29) 13 (10.83) 33 (25.38) 8 (5.33)
p value
Odds ratio (95% CI)
< 0.001*
1.76 (0.08–0.39)
0.112
0.46 (0.19–1.16)
< 0.001*
1.66 (0.07–0.37)
-
A20C Genotypes
AA
46 (65.70) 37 (61.7) 45 (69.23) 53 (70.67)
AC 21 (30.00) 22 (36.7) 19 (29.23) 21 (28.00)
CC 3 (4.30) 1 (1.6) 1 (1.54) 1 (1.33)
A20C Alleles
A
113 (80.70) 96 (80.00) 109 (83.80) 127 (84.67)
C 27 (19.30) 24 (20.00) 21 (16.20) 23 (15.33)
p value
Odds ratio (95% CI)
0.437
0.76 (0.41–1.40)
0.336
0.72 (0.39–1.36)
0.871
0.94 (0.49–1.71)
-
MboI Genotypes
(-/-)
46 (65.71) 43 (71.67) 47 (72.31) 56 (74.67)
(-/+) 22 (31.43) 16 (26.67) 15 (23.08) 18 (24.00)
(+/+) 2 (2.86) 1 (1.67) 3 (4.62) 1 (1.33)
MboI Alleles
(-)
114 (81.43) 102 (85.00) 109 (83.85) 130 (86.67)
(+) 26 (18.57) 18 (15.00) 21 (16.15) 20 (13.33)
p value
Odds ratio (95% CI)
0.261
0.67 (0.36–1.27)
0.727
0.87 (0.44–1.73)
0.612
0.80 (0.41–1.55)
 
Lys173Arg Genotypes
Lys173/Lys
37 (52.86) 22 (36.66) 34 (52.31) 37 (49.33)
Lys173/Arg 31 (44.28) 37 (61.67) 30 (46.15) 37 (49.33)
Arg173/Arg 2 (2.86) 1 (1.67) 1 (1.54) 1 (1.34)
Lys173Arg Alleles
Lys173
105 (75.00) 81 (67.50) 98 (75.38) 111 (74.00)
Arg173 35 (25.00) 39 (32.50) 32 (24.62) 39 (26.00)
p value
Odds ratio (95% CI)
0.893
1.05 (0.62–1.79)
0.280
0.73 (0.43–1.24)
0.891
1.08 (0.63–1.85)
-
Gly460Trp Genotypes
Gly460/Gly
36 (51.43) 28 (46.67) 26 (40.00) 40 (53.33)
Gly460/Trp 13 (18.57) 21 (35.00) 17 (26.15) 21 (28.00)
Trp460/Trp 21 (30.00) 11 (18.33) 22 (33.85) 14 (18.67)
Gly460Trp Alleles
Gly460
85 (60.71) 77 (64.17) 69 (53.08) 96 (64.00)
Trp460 55 (39.29) 43 (35.83) 61 (46.92) 54 (36.00)
p value
Odds ratio (95% CI)
0.564
0.87 (0.54–1.40)
1.000
1.01 (0.61–1.66)
0.064
0.63 (0.39–1.03)
-
  1. Data are reported as number of subjects with percent in parentheses, Group 1- EHT, Group 2 -T2DM, Group 3- EHT+T2DM and Group 4-Control subjects,*P value < 0.001 vs. Group 4.