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Table 2 Lactate:pyruvate ratios in Type 2 diabetic hearts

From: Polyol pathway and modulation of ischemia-reperfusion injury in Type 2 diabetic BBZ rat hearts

Group n Lactate/Pyruvate ratio
Non-diabetic controls 12 16.8 ± 3.2
Type 2 diabetics
12 weeks duration 9 41.4 ± 8.8*
48 weeks duration 5 77.5 ± 12.2*
Aldose reductase inhibited Type 2 diabetics
12 weeks duration 7 7.2 ± 1.8
48 weeks duration 5 10.5 ± 3.2
Sorbitol dehydrogenase inhibited Type 2 diabetics
12 weeks duration 7 8.9 ± 2.1
48 weeks duration 5 12.6 ± 3.4
  1. * p < 0.05 vs non-diabetic controls. The lactate/pyruvate ratios were measured after perfusion for one hour under normoxic conditions.