Figure 2From: Are the adverse effects of glitazones linked to induced testosterone deficiency?The metabolic and clinical effects of adipocyte activity. The adipocyte as the 'Axis of Evil' – PPARγ agonists such as the glitazones stimulate the adipocyte to produce adipocytokines and cause insulin resistance, dyslipidaemias, hypertension, and impaired immunological responses, which together can have the adverse clinical consequences shown.Back to article page