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Figure 3 | Cardiovascular Diabetology

Figure 3

From: Rosiglitazone but not losartan prevents Nrf-2 dependent CD36 gene expression up-regulation in an in vivo atherosclerosis model

Figure 3

Treatments preserve PPARγ activity and PPARγ responsive gene expression. (a) PPARγ mRNA relative expression in pooled liver samples from analyzed groups normalized to GAPDH expression. Results are expressed as mean ± SEM percentage of mean values obtained from equal numbers of C57BL/6J and C3He/6J mice. *P < 0.05. (b). SCARB1 mRNA relative expression in liver samples from analyzed groups normalized to GAPDH expression. *P < 0.05 (c). ChIP with a PPARγ antibody of study groups was used to amplify a SCARB1 promoter fragment. ChIP figures percentages indicate increments or decrements regarding C57BL/6J mice fed HFHC diet. Data of C57BL/6J mice fed chow diet was established as 100%.

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Cardiovascular Diabetology

ISSN: 1475-2840