|
Parameters
|
HC
|
Metformin (months)
|
Rosiglitazone (months)
|
|---|
| | |
0
|
1
|
2
|
0
|
2
|
|---|
|
Fundus
|
neg
|
neg
|
neg
|
neg
|
neg
|
neg
|
|---|
|
MAP (mm Hg)
|
87.0 ± 2.2
|
99 ± 3.2
|
98.1 ± 1.4
|
99.1 ± 3.6
|
96.1 ± 2.0
|
96.2 ± 0.2
|
|
Glucose (mg/dL)
|
94.0 ± 11.9
|
228.4 ± 15.1b
|
135.3 ± 8.3a,b
|
135.9 ± 3.2a,b
|
235.2 ± 15.8b
|
143.1 ± 14.1a,b
|
|
HbA1c (μmol/L)
|
5.4 ± 0.2
|
8.9 ± 0.3b
|
7.2 ± 0.5a,b
|
7 ± 0.1a,b
|
10.7 ± 0.6b
|
7 ± 0.3a,b
|
|
Calculated GFR
|
94.6 ± 2.9
|
99.5 ± 2.1
|
95.7 ± 2.0
|
94.6 ± 2.9
|
95.4 ± 4.8
|
90.1 ± 4.1
|
|
Cholesterol (mg/dL)
|
205.0 ± 1.7
|
203 ± 8.6
|
188.3 ± 9.9
|
188.3 ± 2.2
|
207.3 ± 9.0
|
195.1 ± 4.8
|
|
Triglycerides (mg/dL)
|
120.4 ± 3.2
|
153.2 ± 2.1
|
114.6 ± 26.3
|
129.3 ± 6.5
|
190.2 ± 3.5
|
141.4 ± 5.5
|
|
HDL (mg/dL)
|
58.6 ± 0.7
|
45.9 ± 2.5
|
44.7 ± 3.4
|
43.9 ± 0.9
|
42.04 ± 2.4
|
41.3 ± 0.9
|
|
LDL (mg/dL)
|
114.6 ± 1.3
|
128.4 ± 7.5
|
120.7 ± 8.7
|
118.6 ± 2.1
|
130.0 ± 7.7
|
114.7 ± 2.6
|
|
Hb (g/dL)
|
14.3 ± 0.1
|
14.6 ± 0.4
|
14.0 ± 0.6
|
14.8 ± 0.5
|
14.7 ± 0.3
|
14.4 ± 0.1
|
|
ALT (U/L)
|
20.3 ± 0.5
|
27.3 ± 2.8
|
28.4 ± 5
|
20.3 ± 0.5
|
33.5 ± 6.5
|
24.3 ± 0.7a
|
|
AST (U/L)
|
19.6 ± 0.3
|
19.2 ± 1.5
|
24 ± 3.6
|
19.6 ± 0.3
|
23 ± 3
|
17.4 ± 0.3a
|
|
ALP (U/L)
|
76.2 ± 6.1
|
87.3 ± 4.8b
|
73.7 ± 3.9a
|
76.2 ± 6.1a
|
83.8 ± 4.5b
|
75.3 ± 1.5a
|
|
LDH (U/L)
|
283.3 ± 1.9
|
311 ± 17
|
273.2 ± 10.8
|
283.3 ± 1.9
|
270.4 ± 10.8
|
255.8 ± 3.3
|
|
Insulin (μU/mL)
|
7.6 ± 0.8
|
15.2 ± 1.4b
|
13.5 ± 1.0b
|
11.1 ± 0.9a,b
|
17.5 ± 1.8b
|
9.5 ± 0.4a,b
|
- a P < 0.05, treated DM patients vs. untreated DM patients;
- b P < 0.05, untreated DM patients vs. HC subjects
