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Table 3 Chromosomal location, tissue distribution and transcript information of genes encoding glucose transporters

From: Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats

Gene Symbol

Gene name

Chromosomal Location

Tissue Distribution

Function

Transcript Information

Slc2a1

facilitated glucose transporter member 1 (Glucose transporter type 1) (GLUT-1)

chr5:139690804–139719021

All tissues (abundant in brain and erythrocytes)

Basal uptake

Exons: 10

Transcript length: 2,365 bps

Protein length: 492 residues

Slc2a2

solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2) (GLUT-2)

chr2:116036427–116065870

Liver, pancreatic islet cells, retina

Glucose sensing

Exons: 12

Transcript length: 2,578 bps

Protein length: 524 residues

Slc2a3

solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3) (GLUT-3)

chr4:159210019–159221248

All tissues specially the brain

Supplements GLUT1 in tissues with high energy demand

Exons: 9

Transcript length: 1,467 bps

Protein length: 488 residues

Slc2a4

solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4) (GLUT-4).

chr10:56,786,705–56,792,209.

Muscle, fat, heart

Insulin responsive

Exons: 11

Transcript length: 2,506 bps

Protein length: 509 residues

Slc2a8

solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8)

chr3:11962578–11972099

hippocampal neurons, testis, whole brain

 

Exons: 10

Transcript length: 2,087 bps

Protein length: 478 residues

Naglt1

Sodium dependant glucose transporter 1

chr20:44,147,331–44,176,308.

In all cells

 

Exons: 4

Transcript length: 1,455 bps

Protein length: 484 residues

Slc37a4

solute carrier family 37 (glucose-6-phosphate transporter), member 4

chr 8: 47,363,896–47,369,981.

Liver, Adipocytes

 

Exons: 9

Transcript length: 2,080 bps

Protein length: 429 residues