Table 3 Change from baseline in 24-h ambulatory BP and heart rate at 6 and 12 months
| Â | Background metformin | Background sulfonylurea | ||||
|---|---|---|---|---|---|---|
| Â | + rosiglitazone (n = 176) | + sulfonylurea (n = 165) | difference (95% CI), p-value | + rosiglitazone (n = 160) | + metformin (n = 167) | difference (95% CI), p-value |
ystolic BP change (mmHg) | ||||||
6 months | -3.1 (-4.8, -1.4) | -1.6 (-3.5, + 0.3) | -1.5 (-3.6, 0.6), NS | -3.8 (-5.8, -1.8) | -1.2 (-3.0, + 0.7) | -2.7 (-4.9, -0.5), 0.015 |
12 months | -4.9 (-6.7, -3.2) | -2.2 (-4.2, -0.3) | -2.7 (-4.9, -0.5), 0.016 | -3.8 (-5.9, -1.8) | -1.3 (-3.3, + 0.7) | -2.5 (-4.8, -0.2), 0.031 |
Diastolic BP change (mmHg) | ||||||
6 months | -2.8 (-3.8, -1.9) | -1.6 (-2.7, -0.5) | -1.3 (-2.5, -0.0), 0.049 | -3.1 (-4.2, -2.0) | -0.4 (-1.6, + 0.7) | -2.7 (-4.0, -1.4), < 0.001 |
12 months | -3.8 (-4.9, -2.7) | -1.7 (-2.9, -0.5) | -2.1 (-3.4, -0.7), 0.003 | -3.7 (-4.9, -2.5) | -0.6 (-1.7, + 0.6) | -3.1 (-4.5, -1.8), < 0.001 |
Heart rate change (beat/min) | ||||||
6 months | -0.4 (-1.6, + 0.8) | -0.1 (-1.3, + 1.0) | -0.3 (-1.7, 1.1), NS | -0.7 (-1.9, + 0.5) | 1.3 (+ 0.1, + 2.6) | -2.0 (-3.4, -0.6), 0.006 |
12 months | -0.9 (-2.2, + 0.4) | 0.0 (-1.3, + 1.3) | -0.9 (-2.5, 0.7), NS | -0.9 (-2.3, + 0.5) | 1.7 (+ 0.3, + 3.1) | -2.6 (-4.2, -1.0), 0.002 |