Table 3 Effect of irbesartan on metabolic parameters in patients with metabolic syndrome
Parameter | Baseline | On Therapy | Changea | Changeb | p-valuec |
|---|---|---|---|---|---|
Body weight [kg] | 91.4 ± 15.0 | 89.3 ± 14.6 | -2.1 ± 7.9 | -2.3 | < 0.0001 |
Waist-circumference [cm] | 106.4 ± 13.6 | 104.3 ± 13.2 | -2.1 ± 7.9 | -2.0 | < 0.0001 |
RRsystolic [mmHg] | 157.4 ± 14.7 | 135.0 ± 10.7 | -22.3 ± 15.3 | -14.2 | < 0.0001 |
RRdiastolic [mmHg] | 92.9 ± 9.2 | 80.8 ± 6.8 | -12.1 ± 9.9 | -13.0 | < 0.0001 |
Glucose [mg/dl] | 126.4 ± 37.1 | 114.5 ± 29.4 | -12.0 ± 30.7 | -9.5 | < 0.0001 |
HbA1c [%] | 6.74 ± 1.14 | 6.43 ± 0.91 | -0.31 ± 0.75 | -4.6 | < 0.0001 |
LDL-cholesterol [mg/dl] | 144.9 ± 38.2 | 129.1 ± 31.8 | -15.8 ± 30.5 | -10.9 | < 0.0001 |
HDL-cholesterol [mg/dl] | 48.4 ± 31.8 | 51.0 ± 15.9 | 2.6 ± 31.8 | 5.4 | < 0.0001 |
Triglycerides [mg/dl] | 217.4 ± 114.9 | 182.5 ± 76.7 | -34.9 ± 100.9 | -16.1 | < 0.0001 |
Gamma-GT [U/l] | 52.9 ± 47.1 | 46.8 ± 38.9 | -6.1 ± 30.2 | -11.5 | < 0.0001 |
Hs-CRP [mg/l] | 4.81 ± 7.95 | 4.01 ± 6.74 | -0.79 ± 6.72 | -16.4 | < 0.0001 |