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Table 1 Left ventricular function at baseline, during, and after volume overload in the control and diabetic groups.

From: Noninvasive and invasive evaluation of cardiac dysfunction in experimental diabetes in rodents

Parameter Group (n = 7) BASELINE VOLUME OVERLOAD POST VOLUME OVERLOAD
    1 min 2 min 3 min 1 min 2 min 3 min
LVSP C 136 ± 4.7 125 ± 6.5 135 ± 7 134 ± 6 139 ± 7.8 134 ± 8.8 138 ± 6
(mm Hg) D 114 ± 6* 116 ± 5.8* 112 ± 5 * 114 ± 6 * 107 ± 10 * 102 ± 4 * 107 ± 10*
LVEDP C 4.6 ± 0.3 7.8 ± 0.6 8.0 ± 0.6 9.1 ± 0.56 11 ± 1.3 9 ± 1.1 9.4 ± 1.1
(mm Hg) D 7.4 ± 0.2* 9.9 ± 0.5*# 12.3 ± 0.55*# 11.5 ± 0.72*# 17 ± 1.3 *#† 16 ± 0.7 *#† 15 ± 1.1 *#†
HR C 350 ± 14 327 ± 10 333 ± 11.5 340 ± 7.5 352 ± 5 360 ± 6 360 ± 6
(beats/min) D 307 ± 8.5* 300 ± 6 * 300 ± 7* 302 ± 7* 297 ± 1.5* 298 ± 2* 294 ± 3.5 *
+dP/dt max C 9229 ± 463 8052 ± 741 8699 ± 653 8595 ± 457 8858 ± 504 9273 ± 569 9264 ± 603
(mm Hg/sec) D 6566 ± 609 * 5861 ± 584 * 5760 ± 770 * 6087 ± 1017* 5320 ± 1287 * 5844 ± 1217* 5712 ± 1247*
-dP/dt max C -6845 ± 379 -6446 ± 576 -6543 ± 600 -6139 ± 514 -6672 ± 646 -6320 ± 858 -6272 ± 707
(mm Hg/sec) D -4746 ± 589* -4804 ± 580* -4678 ± 580* -4152 ± 694* -3706 ± 614 * -3557 ± 561* -3246 ± 653*
  1. Data are reported as means ± SEM; LVSP: left ventricle systolic pressure; HR: heart rate; LVEDP: left ventricle end diastolic pressure; +dP/dt max: maximum rate of left ventricle pressure rise; -dP/dt max: maximum rate of left ventricle pressure fall; C: control group; D: diabetic group. * P ≤ 0.05 vs. controls; #P < 0.05 vs. baseline values; † P < 0.05 vs. volume overload values (2-way ANOVA).