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Figure 2 | Cardiovascular Diabetology

Figure 2

From: Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products

Figure 2

Stimulation of HUVEC by various S100 proteins for 48 h after 72 h preincubation with AGEs or albumin-glucose for control: Only after AGE pretreatment, 1 μM S100A8/S100A9 (24 μg/ml) induced a marked increase of IL-6 (a), sICAM-1 (b) and sVCAM-1 (c). MCP-1 (d) release was induced by S100A8/S100A9 irrespective of AGE pretreatment. 1 μM of S100A1 or S100B exhibited no effect.

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Cardiovascular Diabetology

ISSN: 1475-2840