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Table 2 Comparison of mRNA expression in Epicardial Fat from CAD patients with Fat Depots from non CAD Subjects

From: Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease

  Human CAD Patients Non-CAD Human Fat Depots
  Epicardial n = 46 Abdominal SC n = 30 Omental n = 14 Thigh n = 13
  ΔCt ± SEM ΔCt ± SEM % Expression Relative to Epicardial ΔCt ± SEM % Expression Relative to Epicardial ΔCt ± SEM % Expression Relative to Epicardial
TNF-α 19.74 ± 0.36 19.19 ± 0.50 146 19.46 ± 0.20 121 19.86 ± 0.46 92
AGT 17.19 ± 0.31 18.08 ± 0.32 54 17.10 ± 0.62 106 18.16 ± 0.32 ↓51*
PAI-1 19.37 ± 0.41 18.01 ± 0.48 ↑257* 17.76 ± 0.54 ↑305* 19.76 ± 0.57 76
t-Pa 15.38 ± 0.24 16.38 ± 0.18 ↓50* 14.95 ± 0.32 135 16.73 ± 0.34 ↓39*
IL-6 23.08 ± 0.83 19.83 ± 0.99 ↑951* 18.19 ± 0.86 ↑2965** 21.52 ± 0.71 ↑295*
Leptin 15.31 ± 0.41 14.07 ± 0.23 ↑236* 16.50 ± 0.79 44 13.74 ± 0.21 ↑297**
CD 45 18.13 ± 0.46 21.46 ± 0.36 ↓10** 20.44 ± 0.27 ↓20** 19.79 ± 0.38 ↓32**
  1. Expression of mRNA (ΔCt ± SEM) for each gene and depot was analysed. Expression in each depot was compared with that in epicardial adipose tissue from CAD patients which was arbitrarily assigned the value of 100%. Significant increases (↑) and decreases (↓) are highlighted (P-values: * P < 0.05, ** P < 0.01).