Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease

Table 2 Comparison of mRNA expression in Epicardial Fat from CAD patients with Fat Depots from non CAD Subjects

	Human CAD Patients	Non-CAD Human Fat Depots
	Epicardial n = 46	Abdominal SC n = 30		Omental n = 14		Thigh n = 13
	ΔCt ± SEM	ΔCt ± SEM	% Expression Relative to Epicardial	ΔCt ± SEM	% Expression Relative to Epicardial	ΔCt ± SEM	% Expression Relative to Epicardial
TNF-α	19.74 ± 0.36	19.19 ± 0.50	146	19.46 ± 0.20	121	19.86 ± 0.46	92
AGT	17.19 ± 0.31	18.08 ± 0.32	54	17.10 ± 0.62	106	18.16 ± 0.32	↓51*
PAI-1	19.37 ± 0.41	18.01 ± 0.48	↑257*	17.76 ± 0.54	↑305*	19.76 ± 0.57	76
t-Pa	15.38 ± 0.24	16.38 ± 0.18	↓50*	14.95 ± 0.32	135	16.73 ± 0.34	↓39*
IL-6	23.08 ± 0.83	19.83 ± 0.99	↑951*	18.19 ± 0.86	↑2965**	21.52 ± 0.71	↑295*
Leptin	15.31 ± 0.41	14.07 ± 0.23	↑236*	16.50 ± 0.79	44	13.74 ± 0.21	↑297**
CD 45	18.13 ± 0.46	21.46 ± 0.36	↓10**	20.44 ± 0.27	↓20**	19.79 ± 0.38	↓32**

Expression of mRNA (ΔCt ± SEM) for each gene and depot was analysed. Expression in each depot was compared with that in epicardial adipose tissue from CAD patients which was arbitrarily assigned the value of 100%. Significant increases (↑) and decreases (↓) are highlighted (P-values: * P < 0.05, ** P < 0.01).

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