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Table 6 The positve protective effects of Endothelial Nitric Oxide Synthase (Enos) and Endothelial Nitric Oxide (eNO)

From: The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded

The positve protective effects of eNOS – eNO
1. Promotes vasodilatation of vascular smooth muscle.
2. Counteracts smooth muscle cell proliferation.
3. Decreases platelet adhesiveness.
4. Decreases adhesiveness of the endothelial layer to WBCs (monocytes). Thus, the .... "Teflon effect".
5. Anti- inflammatory.
6. Anti- oxidant. It scavenges reactive oxygen species, locally.
Acts as a chain – breaking antioxidant to scavenge ROS.
7. Anti- fibrotic. When NO is normal or elevated MMPs are low and conversely if NO is low MMPs are elevated and active. MMPs are redox sensitive.
8. NO has diverse anti-atherosclerotic actions on the arterial vessel wall: including antioxidant effects by direct scavenging of ROS – RNS acting as chain breaking antioxidants and anti-inflammatory effects