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Table 5 Extracellular matrix degradation mechanisms: Focus on MMP

From: The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded

Type Examples Location Examples of Substrates
Serine protease Plasmin, urokinase, cathepsin G, TPA Pericellular Extracellular Fibrin, fibronectin, laminin, some proteoglycans
Cysteine protease Cathepsins B, D, H, L, N, and S Generally Cytosol-lysosomal Collagen, elastin. & proteoglycans
MMPs: Matrix Metalloproteinases Interstitial collagenases (MMP-1) Extracellular Collagens I, II, III, VII, and X
Basement Membrane Gelatinase A (MMP-2) 72 kDa Extracellular Collagens IV – BM, V, VII, and X Elastinolytic
  Stromelysin-1 (MMP-3) Extracellular Collagens IV, III, V, and IX; laminin, fibronectin, elastin, proteoglycans
  PUMP-1 (MMP-7) Extracellular Gelatin, fibronectin, laminin, collagen type IV, procollagenase, and proteoglycan core protein
Of Emerging Importance! [134] Neutrophil Elastase - collagenase
(MMP-8): Activated by CD-40 ligand
Extracellular Macrophage
Endothelial Cell of Vasa Vasorum
Collagens I, II, and III and proteoglycans Elastinolytic Internal Elastic Lamina. Activates MMP-2 -9
Basement Membrane Gelatinase B (MMP-9) 92 kDa Extracellular Collagens IV – BM V, VII, and plus Elastinolytic
  Stromelysin-2 (MMP-10) Extracellular Similar to stromelysin-1
  Stromelysin-3 (MMP-11) Extracellular Gelatin, fibronectin, and proteoglycans
  Metalloelastase (MMP-12) Extracellular Elastin
Membrane type MMP MT-MMP (MMP-14) Cell surface Collagen IV, gelatin, and progelatinase A
Cardiac integrin MMP Disintegrin Metalloproteinse (DMP) Membrane type integrin matrix degrading MMP Endothelial Cardiac Integrin