Type | Examples | Location | Examples of Substrates |
---|---|---|---|
Serine protease | Plasmin, urokinase, cathepsin G, TPA | Pericellular Extracellular | Fibrin, fibronectin, laminin, some proteoglycans |
Cysteine protease | Cathepsins B, D, H, L, N, and S | Generally Cytosol-lysosomal | Collagen, elastin. & proteoglycans |
MMPs: Matrix Metalloproteinases | Interstitial collagenases (MMP-1) | Extracellular | Collagens I, II, III, VII, and X |
Basement Membrane | Gelatinase A (MMP-2) 72 kDa | Extracellular | Collagens IV – BM, V, VII, and X Elastinolytic |
 | Stromelysin-1 (MMP-3) | Extracellular | Collagens IV, III, V, and IX; laminin, fibronectin, elastin, proteoglycans |
 | PUMP-1 (MMP-7) | Extracellular | Gelatin, fibronectin, laminin, collagen type IV, procollagenase, and proteoglycan core protein |
Of Emerging Importance! [134] | Neutrophil Elastase - collagenase (MMP-8): Activated by CD-40 ligand | Extracellular Macrophage Endothelial Cell of Vasa Vasorum | Collagens I, II, and III and proteoglycans Elastinolytic Internal Elastic Lamina. Activates MMP-2 -9 |
Basement Membrane | Gelatinase B (MMP-9) 92 kDa | Extracellular | Collagens IV – BM V, VII, and plus Elastinolytic |
 | Stromelysin-2 (MMP-10) | Extracellular | Similar to stromelysin-1 |
 | Stromelysin-3 (MMP-11) | Extracellular | Gelatin, fibronectin, and proteoglycans |
 | Metalloelastase (MMP-12) | Extracellular | Elastin |
Membrane type MMP | MT-MMP (MMP-14) | Cell surface | Collagen IV, gelatin, and progelatinase A |
Cardiac integrin MMP | Disintegrin Metalloproteinse (DMP) | Membrane type integrin matrix degrading MMP | Endothelial Cardiac Integrin |