Table 4 A representation of proteoglycans I – IV present in vascular ECM
Family (location) | Common name | Function |
|---|---|---|
I. Large (interstitial) | Versican (CSPG) | Compression resilience. Similar to Hyaluronan |
II. Small (leucine-rich) | Decorin Biglycan Lumican | Collagen organization. |
III. Basement membrane Recently discovered → In diabetic renal BM the CSPG Bamacan may be substituted for the HSPG Perlecan | Perlecan (HSPG) Bamacan (CSPG) (galactosaminoglycan chains) Agrin (HSPG) | Anionic filtration barrier Binds growth factors Neural tight junctions (Blood Brain Barrier) and in renal BM |
IV. Cell surface (Plasma membrane). I.- IV. Present in vascular ECM The vascular SMC is the principal source for these vascular proteoglycans. | Syndecan-1 Fibroglycan N-Syndecan (HSPG) Ryudocan Glypican (HSPG) | ECM receptors, growth factor receptors. Binds coagulant enzymes, cytokines, and lipases. |
V. Cerebral Proteoglycans Others: | Cerebrocan Neurocan (CSPG) Phosphacan (CSPG) Brevican (CSPG) _______ Aggrecan Betaglycan | Prominent in cartilage |