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Table 4 A representation of proteoglycans I – IV present in vascular ECM

From: The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded

Family (location) Common name Function
I. Large (interstitial) Versican (CSPG) Compression resilience. Similar to Hyaluronan
II. Small (leucine-rich) Decorin
Biglycan
Lumican
Collagen organization.
III. Basement membrane Recently discovered →
In diabetic renal BM the CSPG Bamacan may be substituted for the HSPG Perlecan
Perlecan (HSPG)
Bamacan (CSPG) (galactosaminoglycan chains)
Agrin (HSPG)
Anionic filtration barrier Binds growth factors
Neural tight junctions (Blood Brain Barrier) and in renal BM
IV. Cell surface (Plasma membrane).
I.- IV.
Present in vascular ECM The vascular SMC is the principal source for these vascular proteoglycans.
Syndecan-1
Fibroglycan
N-Syndecan (HSPG)
Ryudocan
Glypican (HSPG)
ECM receptors, growth factor receptors. Binds coagulant enzymes, cytokines, and lipases.
V. Cerebral Proteoglycans
Others:
Cerebrocan
Neurocan (CSPG)
Phosphacan (CSPG)
Brevican (CSPG)
_______
Aggrecan
Betaglycan
Prominent in cartilage