|
Variable
|
Least-squares mean percentage change from baseline to 4 weeks
|
Difference (95% CI)
|
p-value
|
|---|
|
Rosuvastatin 10 mg (n = 232)
|
Atorvastatin 10 mg (n = 231)
|
|---|
|
LDL-C
|
-47.6
|
-38.5a
|
-9.1 (-11.4, -6.7)
|
< 0.0001
|
|
TC
|
-33.6
|
-27.9
|
-5.7 (-7.4, -4.0)
|
< 0.0001
|
|
HDL-C
|
4.4
|
2.6
|
1.8 (-0.5, 4.0)
|
NS
|
|
TG
|
-19.2
|
-15.5
|
-3.7 (-9.5, 2.2)
|
NS
|
|
Non-HDL-C
|
-42.6
|
-35.0
|
-7.6 (-9.6, -5.7)
|
< 0.0001
|
|
LDL-C/HDL-C ratio
|
-49.3
|
-39.5
|
-9.8 (-12.2, -7.4)
|
< 0.0001
|
|
Non-HDL-C/HDL-C ratio
|
-44.4
|
-35.9
|
-8.5 (-10.8, -6.2)
|
< 0.0001
|
|
TC/HDL-C ratio
|
-35.8
|
-29.0
|
-6.7 (-8.7, -4.8)
|
< 0.0001
|
|
Apo B
|
-42.9
|
-35.3
|
-7.6 (-9.7, -5.6)
|
< 0.0001
|
|
Apo A-I
|
2.6
|
0.8
|
1.8 (0, 3.5)
|
0.05
|
|
Apo B/apo A-I ratio
|
-43.9
|
-35.4
|
-8.5 (-10.6, -6.4)
|
< 0.0001
|
- ITT: Intention to treat, CI: Confidence interval, LDL-C: Low-density lipoprotein cholesterol, TC: Total cholesterol, HDL-C: High-density lipoprotein cholesterol, TG: Triglycerides, Apo: Apolipoprotein, NS: Not statistically significant
- an = 232
