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Figure 1 | Cardiovascular Diabetology

Figure 1

From: Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice

Figure 1

Generation of reactive species in diabetes. Highlighted in gray are some of the most important ROS and RNS in vascular cells. Oxygen is converted to O2- via the activation of enzymatic and nonenzymatic pathways, which is then dismutated to H2O2 by SOD. H2O2 can be converted to H2O by catalase or glutathione peroxidase (GSH-Px) or to OH after reaction with Cu or Fe. Glutathione reductase regenerates glutathione (GSH). In addition, O2- reacts rapidly with NO to form ONOO-.

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