|Positive Regulators||Negative Regulators|
|Minerals: Ca ++ Pi, Phosphate/Pit-1 → Cbfa-1||Fetuin-A|
Bone morphogenic protein
Matrix gammacarboxyglutamate (Gla)-protein
|Warfarin may also cause skin necrosis similar to CPLX via an impairment of Protein C with thrombosis in venules resulting in subcutaneous ischemia and Vitamin K – GLA inhibition.||
|Inflammation: TNFalpha, IL-6||IL-10|
|Oxidized – retained – modified lipids (OxLDL-C, OxVLDL beta lipoproteins) and Low alpha lipoproteins: HDL-C||
(may be a positive and negative regulator)
Elevated in human atherosclerosis and CVD yet paradoxically when you have a mouse model with knockout of OPG there is increased osteoporosis and VOC.
|A-FLIGHT TOXICITIES (table 3)|
|Hormones: Insulin, IGF-1, Amylin, Leptin, and PTH|
|I or II Hyperparathyroidism|
HYPOXIA activates hypoxia inducible factor Hif-1, ROS → Vascular angiogenesis
Multipotential → Pericyte
RANK and RANKL
These are involved but as with OPG the entire story is still evolving.