Matrix vesicle formation at the base of the lipid core. This image depicts the formation of matrix vesicles at the base of the lipid core in an atherosclerotic plaque. These vesicles are generated through the wound healing process and act as a nidus for later plaque ossification. A 32 year-old male smoker killed in a motorcycle accident. Left anterior descending coronary artery. Note the basophilic staining at the base of the lipid core (starred) and surrounding areas. This area represents early changes of atheromatous ossification. Coronary artery calcification may not be detected until later in life, however this image portrays VOC as being an active directed process beginning early in life.