Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes

Table 4 Multivariate associations of risk factors with PAD

Dependent variable	Independent variable	Unit	OR (95% CI)	P
PAD, left or right	MTHFR 677C>T	677C/T	3.54 (1.01, 12.4)	0.049
	oral treatment for diabetes	+	0.31 (0.082, 1.20)	NS (0.091)
	current smoker	+	3.04 (0.82, 11.2)	NS (0.095)
	hypertension	+	2.58 (0.58, 11.6)	NS (0.22)
	age	10 yr	1.36 (0.80, 2.29)	NS (0.26)
	duration of diabetes	5 yr	0.79 (0.45, 1.38)	NS (0.41)
	insulin administration	+	0.96 (0.18, 5.08)	NS (0.97)
	sex	male	1.00 (0.30, 3.34)	NS (0.99)

Hypertension: systolic blood pressure ≥ 130 and/or diastolic blood pressure ≥ 80 and/or antihypertensive treatment.
Abbreviations: OR, odds ratio; PAD, peripheral arterial disease; MTHFR, methylenetetrahydrofolate reductase; NS, not significant.

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