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Table 2 Characteristics of Oji-Cree type 2 diabetic patients according to MTHFR 677C>T genotype (max n = 138)

From: Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes

  N 677C/C 677C/T P
N (men/women) 138 108 (41/67) 30 (8/22) NS (0.25)
Age (years) 138 46.4 ± 11.1 45.1 ± 13.5 NS (0.60)
BMI (kg/m2) 137 29.7 ± 4.7 32.6 ± 5.5 0.0050
Waist circumference (cm) 137 103 ± 9 106 ± 11 NS (0.063)
Current smoker (%) 138 50.0 50.0 NS (1.00)
Duration of diabetes (years) 138 8.53 ± 6.35 9.20 ± 7.01 NS (0.62)
Fasting glucose (mmol/L) 130 10.20 ± 3.91 9.28 ± 3.03 NS (0.33)
HbA1c (%) 136 8.36 ± 2.25 8.66 ± 2.18 NS (0.47)
Total cholesterol (mmol/L) 133 4.91 ± 1.07 4.67 ± 0.82 NS (0.27)
HDL-C (mmol/L) 133 1.21 ± 0.29 1.21 ± 0.29 NS (0.91)
LDL-C (mmol/L) 130 2.75 ± 0.71 2.70 ± 0.67 NS (0.78)
Plasma triglycerides (mmol/L) 133 2.20 ± 2.78 1.66 ± 0.60 NS (0.15)
Systolic BP (mmHg) 138 123 ± 16 132 ± 22 0.021
Diastolic BP (mmHg) 138 73.9 ± 8.9 77.4 ± 9.4 NS (0.077)
Hypertensive (%) 138 62.0 66.7 NS (0.64)
CRP (mg/L) 133 4.91 ± 6.65 6.53 ± 8.37 NS (0.19)
ABI, left 138 1.08 ± 0.09 1.05 ± 0.12 NS (0.26)
ABI, right 138 1.08 ± 0.09 1.07 ± 0.13 NS (0.73)
  1. Data are means ± s.d., unless otherwise indicated.
  2. Hypertension: systolic BP ≥ 130 and/or diastolic BP ≥ 80 and/or antihypertensive treatment
  3. Abbreviations: BMI, body mass index; HbA1c, glycosylated hemoglobin; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; BP, blood pressure; CRP, C-reactive protein; ABI, ankle-brachial index; NS, not significant.