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Table 1 Characteristics of Oji-Cree type 2 diabetic patients according to the presence or absence of PAD (max n = 138)

From: Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes

 

PAD present

PAD absent

P

 

N

 

N

  

Sex (% male)

20

35.0

118

35.6

NS (0.96)

Age (years)

20

48.0 ± 11.2

118

45.8 ± 11.7

NS (0.44)

BMI (kg/m2)

20

30.4 ± 5.7

117

30.3 ± 4.9

NS (0.98)

Waist circumference (cm)

20

102 ± 13

117

104 ± 9

NS (0.52)

Current smokers (%)

20

65.0

118

47.5

NS (0.15)

Duration of diabetes (years)

20

8.70 ± 4.64

118

8.67 ± 6.76

NS (0.98)

Insulin treatment (%)

16

25.0

98

18.4

NS (0.51)

Intake of antidiabetic drugs (%)

16

31.3

98

58.2

0.045

Taking lipid medication (%)

20

5.0

118

16.1

NS (0.31)

Fasting glucose (mmol/L)

19

10.27 ± 2.79

111

9.96 ± 3.90

NS (0.48)

HbA1c (%)

20

8.30 ± 1.93

116

8.44 ± 2.29

NS (0.92)

Total cholesterol (mmol/L)

19

4.43 ± 0.63

114

4.93 ± 1.06

0.036

Plasma triglycerides (mmol/L)

19

1.54 ± 0.60

114

2.18 ± 2.68

NS (0.059)

Systolic BP (mmHg)

20

136 ± 21

118

123 ± 16

0.0028

Diastolic BP (mmHg)

20

74 ± 10

118

75 ± 9

NS (0.81)

Hypertensive (%)

20

70.0

118

61.9

NS (0.49)

CRP (mg/L)

19

6.86 ± 12.0

114

4.97 ± 5.87

NS (0.99)

ABI, left

20

0.96 ± 0.12

118

1.09 ± 0.08

<0.0001

ABI, right

20

0.93 ± 0.06

118

1.10 ± 0.08

<0.0001

Intermittent claudication (%)

20

15.0

118

4.2

NS (0.091)

  1. Data are means ± s.d., unless otherwise indicated.
  2. PAD, peripheral arterial disease: ABI <0.95; Hypertension: systolic BP ≥ 130 and/or diastolic BP ≥ 80 and/or antihypertensive treatment.
  3. Abbreviations: BMI, body mass index; HbA1c, glycosylated hemoglobin; BP, blood pressure; CRP, C-reactive protein; ABI, ankle-brachial index; NS, not significant.