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Table 4 Beneficial effects of HDL-C

From: Isolated low high density lipoprotein-cholesterol (HDL-C): implications of global risk reduction. Case report and systematic scientific review

REVERSE CHOLESTEROL TRANSPORT
Accepts cholesterol from the macrophage and tissues and transports it back to the liver for disposal in the bile (figure 1).
Acts a an apoprotein donor to the other lipoproteins
ANTIOXIDANT
Antioxidant activity (through intimal paraoxonase, and redox -sensitive methionine residues of apo A-1)
Increases eNOS and endothelial nitric oxide
ANTIINFLAMMATORY
Downregulates adhesion molecule expression on endothelium: (I-CAM, V-CAM and MCP-1)
Inhibits neutrophil degranulation
ANTITHROMBOTIC
Antithrombotic activity via its ability to block TxA2 and potentiates activity of proteins: C and S.
Stimulates prostacyclin production (antithrombotic and vasodilitory).
ENDOTHELIAL PROTECTION PROTERTIES
Acts as an endothelial mitogen and inhibits endothelial cell apoptosis: This would help to decrease the incidence of plaque erosion and promote plaque stabilization
Stimulates endothelial nitric oxide (eNO and its enzyme eNOS) and prostacyclin production with vasodilatation, antioxidant, and anti-inflammatory properties.