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Table 3 Secondary causes of low HDL-C

From: Isolated low high density lipoprotein-cholesterol (HDL-C): implications of global risk reduction. Case report and systematic scientific review

1. Elevated triglycerides. (Component of metS)
  End stage renal disease
  Hypothyroidism [also increased total Chol/HDL-C ratio.
2. Obesity and Overweight. – [waist measurement] – (Component of metS)
  [Visceral obesity in particular]
  For every 3 kg. (7 lbs.) weight loss HDL-C increased 1 mg/dL.
3. Prediabetes and overt Type 2 Diabetes Mellitus. (Component of metS)
4. Physical inactivity (lifestyle choice).
5. Smoking (lifestyle choice).
6. Very high carbohydrate intakes > 50–60% of energy (lifestyle choice).
  [Especially Fructose Containing Soft Drinks.]
7. Metabolic Syndrome: As potent a risk factor as smoking.
8. Drugs, such as beta-blockers, anabolic steroids, and progestational agents.