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Table 2 Changes in plasma soluble adhesion molecule, matrix metalloproteinase concentrations and LDL oxidisability during a glucose tolerance test in 21 patients with Type 2 diabetes and 20 controls.

From: Plasma matrix metalloproteinases, low density lipoprotein oxidisability and soluble adhesion molecules after a glucose load in Type 2 diabetes

  Time [mins]
  0 60 90 120 p
Type 2 diabetes      
Blood glucose [mmol/l] 8.6 [2.7] 16.1 [3.8] * 17.8 [3.5] * 17.0 [3.6] * 0.0001
s ICAM-1 [ng/ml] 276 [85] 249 [76] * 249 [79] * 247 [78] * 0.0001
s VCAM-1 [ng/ml] 528 [222] 486 [216] * 472 [208] * 459 [194] * 0.0001
s E-Selectin [ng/ml] 82 [33] 76 [31]* 74 [32] * 75 [32] * 0.0001
LDL lag time [mins] 54. 8 [9.8] - 52.2 [9.3]   ns
Plasma triglycerides [mmol/l] 2.5 [0.9] - 2.4 [0.7]   ns
MMP-3 [ng/ml] 13.7 [0 – 71] - 18.0 [0 – 85]   ns
MMP-9 [ng/ml] 0.0 [0 – 129] - 0.0 [0 – 75]   ns
Controls
Time [mins] 0 60 90 120 p
Blood glucose [mmol/l] 4.6 [0.3] 7.0 [1.2] * 6.0 [1.1] * 5.4 [1.1] * 0.0001
s ICAM-1 [ng/ml] 280 [82] 219 [57] * 257 [70] * 230 [71] * 0.0001
s VCAM-1 [ng/ml] 321 [198] 349 [197] 321 [174] 338.7 [182] 0.23
s E-Selectin [ng/ml] 64 [24] 60 [21] 58 [22] ** 59 [21] 0.003
LDL lag time [mins] 71.3 [8.1]   74.3 [10.2]   ns
Plasma triglycerides [mmol/l] 1.6 [0.7]   1.7 [0.8]   ns
MMP-3 [ng/ml] 30.8 [12.8 – 39]   26.4 [4.3 – 37.4]   ns
MMP-9 [ng/ml] 4.7 [1.2 – 41]   11.1 [2.5 – 41.9] *   0.03
  1. Abbreviations as in text. All data shown as mean [SD] or as a median and range [MMP-3 and 9] and p values are for one way repeated measure ANOVA for each variable with * = p < 0.001, ** = p < 0.01 compared to time 0.