Table 2 Changes in plasma soluble adhesion molecule, matrix metalloproteinase concentrations and LDL oxidisability during a glucose tolerance test in 21 patients with Type 2 diabetes and 20 controls.

Type 2 diabetes

Blood glucose [mmol/l]

8.6 [2.7]

16.1 [3.8] *

17.8 [3.5] *

17.0 [3.6] *

0.0001

s ICAM-1 [ng/ml]

276 [85]

249 [76] *

249 [79] *

247 [78] *

0.0001

s VCAM-1 [ng/ml]

528 [222]

486 [216] *

472 [208] *

459 [194] *

0.0001

s E-Selectin [ng/ml]

82 [33]

76 [31]*

74 [32] *

75 [32] *

0.0001

LDL lag time [mins]

54. 8 [9.8]

-

52.2 [9.3]

ns

Plasma triglycerides [mmol/l]

2.5 [0.9]

-

2.4 [0.7]

ns

MMP-3 [ng/ml]

13.7 [0 – 71]

-

18.0 [0 – 85]

ns

MMP-9 [ng/ml]

0.0 [0 – 129]

-

0.0 [0 – 75]

ns

Controls

Time [mins]

0

60

90

120

p

Blood glucose [mmol/l]

4.6 [0.3]

7.0 [1.2] *

6.0 [1.1] *

5.4 [1.1] *

0.0001

s ICAM-1 [ng/ml]

280 [82]

219 [57] *

257 [70] *

230 [71] *

0.0001

s VCAM-1 [ng/ml]

321 [198]

349 [197]

321 [174]

338.7 [182]

0.23

s E-Selectin [ng/ml]

64 [24]

60 [21]

58 [22] **

59 [21]

0.003

LDL lag time [mins]

71.3 [8.1]

74.3 [10.2]

ns

Plasma triglycerides [mmol/l]

1.6 [0.7]

1.7 [0.8]

ns

MMP-3 [ng/ml]

30.8 [12.8 – 39]

26.4 [4.3 – 37.4]

ns

MMP-9 [ng/ml]

4.7 [1.2 – 41]

11.1 [2.5 – 41.9] *

0.03