Table 2 The 10-point process of Angiogenesis:
(See FIGURE 4) |
|---|
1. Endothelial cell activation and Proliferation. |
2. Local Vasodilatation. |
3. Increased vascular permeability. |
4. Accumulation of extravascular fibrin* PAI-1 |
5. Proteolytic degradation of basement membrane. MMP-9 MMP-2 |
6. Thin cytoplasmic processes are extended from the endothelial cell. |
7. Directed migration into surrounding ECM toward the Angiogenic Stimulus (IPH or Ischemia). |
8. E. Cells. elongate and align to form a capillary Sprout. |
9. E. Cell. Division proximal to the migrating tip. |
10. Reconstitution of the basement membrane. |
   • PAI-1 inhibits fibrinolysis. |
   • PAI-1 inhibits uPA and tPA and PLASMIN production: |
   • PAI-1 inhibits the conversion of latent MMPs to active MMPs |
   • THUS interfering with remodeling and arteriogenesis |