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1. Endothelial cell activation and Proliferation.
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2. Local Vasodilatation.
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3. Increased vascular permeability.
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4. Accumulation of extravascular fibrin* PAI-1
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5. Proteolytic degradation of basement membrane. MMP-9 MMP-2
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6. Thin cytoplasmic processes are extended from the endothelial cell.
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7. Directed migration into surrounding ECM toward the Angiogenic Stimulus (IPH or Ischemia).
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8. E. Cells. elongate and align to form a capillary Sprout.
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9. E. Cell. Division proximal to the migrating tip.
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10. Reconstitution of the basement membrane.
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• PAI-1 inhibits fibrinolysis.
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• PAI-1 inhibits uPA and tPA and PLASMIN production:
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• PAI-1 inhibits the conversion of latent MMPs to active MMPs
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• THUS interfering with remodeling and arteriogenesis
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