1. Endothelial cell activation and Proliferation.
|
2. Local Vasodilatation.
|
3. Increased vascular permeability.
|
4. Accumulation of extravascular fibrin* PAI-1
|
5. Proteolytic degradation of basement membrane. MMP-9 MMP-2
|
6. Thin cytoplasmic processes are extended from the endothelial cell.
|
7. Directed migration into surrounding ECM toward the Angiogenic Stimulus (IPH or Ischemia).
|
8. E. Cells. elongate and align to form a capillary Sprout.
|
9. E. Cell. Division proximal to the migrating tip.
|
10. Reconstitution of the basement membrane.
|
• PAI-1 inhibits fibrinolysis.
|
• PAI-1 inhibits uPA and tPA and PLASMIN production:
|
• PAI-1 inhibits the conversion of latent MMPs to active MMPs
|
• THUS interfering with remodeling and arteriogenesis
|